Sanofi KK, Tokyo, Japan.
Kantar Health, New York, USA.
J Dermatol. 2018 Apr;45(4):390-396. doi: 10.1111/1346-8138.14218. Epub 2018 Jan 31.
Atopic dermatitis is a chronic inflammatory skin disease. The objective of this study was to characterize the burden of atopic dermatitis in Japanese adult patients relative to the general population. Japanese adults (≥18 years) with a self-reported diagnosis of atopic dermatitis and adult controls without atopic dermatitis/eczema/dermatitis were identified from the 2013 Japan National Health and Wellness Survey. Atopic dermatitis patients were propensity-score matched with non-atopic dermatitis controls (1:2 ratio) on demographic variables. Patient-reported outcome data on comorbidities, mood and sleep disorders, health-related quality of life, work productivity and activity impairment, and health-care resource utilization were analyzed in atopic dermatitis patients and matched controls. A total of 638 Japanese adult patients with atopic dermatitis were identified, of whom 290 (45.5%) rated their disease as "moderate/severe" and 348 (54.5%) as "mild". The analysis cohort comprised 634 atopic dermatitis patients and 1268 matched controls. Atopic dermatitis patients reported a significantly higher prevalence of arthritis, asthma, nasal allergies/hay fever, anxiety, depression and sleep disorders compared with controls (all P < 0.001). Atopic dermatitis patients also reported a significantly poorer health-related quality of life, higher overall work and activity impairment, and higher health-care resource utilization (all P < 0.001). Self-rated disease severity was not associated with disease burden, except for a significantly higher overall work and activity impairment. In conclusion, Japanese adult patients with atopic dermatitis reported a substantial disease burden relative to adults without atopic dermatitis, suggesting an unmet need for effective strategies targeting disease management.
特应性皮炎是一种慢性炎症性皮肤病。本研究的目的是描述日本成年特应性皮炎患者相对于普通人群的疾病负担。从 2013 年日本国民健康和健康调查中确定了自我报告患有特应性皮炎的日本成年患者（≥18 岁）和无特应性皮炎/湿疹/皮炎的成年对照者。根据人口统计学变量，对特应性皮炎患者进行倾向评分匹配非特应性皮炎对照者（1:2 比例）。分析了特应性皮炎患者和匹配对照者的合并症、情绪和睡眠障碍、健康相关生活质量、工作生产力和活动障碍以及卫生保健资源利用情况的患者报告结果数据。共确定了 638 例日本成年特应性皮炎患者，其中 290 例（45.5%）患者将其疾病评为“中度/重度”，348 例（54.5%）患者评为“轻度”。分析队列包括 634 例特应性皮炎患者和 1268 例匹配对照者。与对照者相比，特应性皮炎患者报告关节炎、哮喘、鼻过敏/花粉症、焦虑、抑郁和睡眠障碍的患病率显著更高（均 P < 0.001）。特应性皮炎患者还报告健康相关生活质量显著较差，整体工作和活动障碍程度更高，卫生保健资源利用率更高（均 P < 0.001）。自我报告的疾病严重程度与疾病负担无关，除了整体工作和活动障碍显著更高。总之，与无特应性皮炎的成年人相比，日本成年特应性皮炎患者报告的疾病负担相当大，表明需要采取有效的疾病管理策略来满足这一需求。
