Sanofi, Chilly-Mazarin, France.
Kantar Health, Princeton, New Jersey.
J Am Acad Dermatol. 2018 Jan;78(1):54-61.e1. doi: 10.1016/j.jaad.2017.08.002. Epub 2017 Oct 7.
There is a lack of data on the burden of atopic dermatitis (AD) in adults relative to the general population.
To characterize the AD burden in adult patients relative to both matched non-AD controls and matched patients with psoriasis in terms of comorbidities, health care resource utilization (HCRU), and costs.
Adults (≥18 years) who self-reported a diagnosis of AD or psoriasis and adult non-AD controls were identified from the 2013 US National Health and Wellness Survey. Patients with AD were propensity score-matched with non-AD controls and patients with psoriasis on demographic variables. Patient-reported outcomes were analyzed between matched cohorts.
Patients with AD had a significantly greater risk for atopic comorbidities, as well as significantly greater HCRU and total cost compared with non-AD controls. The burden of AD was generally comparable to that of psoriasis, although patients with AD reported increased use of emergency room visits compared with patients with psoriasis.
Patient-reported data are susceptible to recall bias and erroneous classification.
Adult patients with AD reported a substantial disease burden, suggesting an unmet need for more effective AD treatment options.
目前针对成人特应性皮炎(AD)的负担相对于普通人群而言,数据较为缺乏。
本研究旨在从合并症、医疗资源利用(HCRU)和成本等方面,描述相对于匹配的非 AD 对照组和匹配的银屑病患者,成人 AD 患者的疾病负担。
从 2013 年美国国家健康和健康调查中确定了自我报告患有 AD 或银屑病的成年患者(≥18 岁)和成年非 AD 对照组。AD 患者根据人口统计学变量与非 AD 对照组和银屑病患者进行倾向评分匹配。对匹配队列中的患者报告结果进行了分析。
与非 AD 对照组相比,AD 患者发生特应性合并症的风险显著更高,HCRU 和总费用也显著更高。AD 的负担通常与银屑病相当,尽管 AD 患者的急诊就诊次数高于银屑病患者。
患者报告的数据易受回忆偏倚和错误分类的影响。
成年 AD 患者报告的疾病负担很大,这表明需要更有效的 AD 治疗选择来满足这一需求。