Suppr超能文献

美国成年人特应性皮炎负担:2013 年国家健康和健康调查的医疗资源利用数据。

The burden of atopic dermatitis in US adults: Health care resource utilization data from the 2013 National Health and Wellness Survey.

机构信息

Sanofi, Chilly-Mazarin, France.

Kantar Health, Princeton, New Jersey.

出版信息

J Am Acad Dermatol. 2018 Jan;78(1):54-61.e1. doi: 10.1016/j.jaad.2017.08.002. Epub 2017 Oct 7.

Abstract

BACKGROUND

There is a lack of data on the burden of atopic dermatitis (AD) in adults relative to the general population.

OBJECTIVE

To characterize the AD burden in adult patients relative to both matched non-AD controls and matched patients with psoriasis in terms of comorbidities, health care resource utilization (HCRU), and costs.

METHODS

Adults (≥18 years) who self-reported a diagnosis of AD or psoriasis and adult non-AD controls were identified from the 2013 US National Health and Wellness Survey. Patients with AD were propensity score-matched with non-AD controls and patients with psoriasis on demographic variables. Patient-reported outcomes were analyzed between matched cohorts.

RESULTS

Patients with AD had a significantly greater risk for atopic comorbidities, as well as significantly greater HCRU and total cost compared with non-AD controls. The burden of AD was generally comparable to that of psoriasis, although patients with AD reported increased use of emergency room visits compared with patients with psoriasis.

LIMITATIONS

Patient-reported data are susceptible to recall bias and erroneous classification.

CONCLUSIONS

Adult patients with AD reported a substantial disease burden, suggesting an unmet need for more effective AD treatment options.

摘要

背景

目前针对成人特应性皮炎(AD)的负担相对于普通人群而言,数据较为缺乏。

目的

本研究旨在从合并症、医疗资源利用(HCRU)和成本等方面,描述相对于匹配的非 AD 对照组和匹配的银屑病患者,成人 AD 患者的疾病负担。

方法

从 2013 年美国国家健康和健康调查中确定了自我报告患有 AD 或银屑病的成年患者(≥18 岁)和成年非 AD 对照组。AD 患者根据人口统计学变量与非 AD 对照组和银屑病患者进行倾向评分匹配。对匹配队列中的患者报告结果进行了分析。

结果

与非 AD 对照组相比,AD 患者发生特应性合并症的风险显著更高,HCRU 和总费用也显著更高。AD 的负担通常与银屑病相当,尽管 AD 患者的急诊就诊次数高于银屑病患者。

局限性

患者报告的数据易受回忆偏倚和错误分类的影响。

结论

成年 AD 患者报告的疾病负担很大,这表明需要更有效的 AD 治疗选择来满足这一需求。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验