Zhang Ningxin, Chi Huiyan, Jin Qiubai, Sun Meiqi, Zhao Yuechun, Song Ping
Department of Dermatology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Haidian District, Beijing, 100091, China.
Department of Dermatology, Guanganmen Hospital of China Academy of Chinese Medical Sciences, Xicheng District, Beijing, 100053, China.
Arch Dermatol Res. 2025 Apr 1;317(1):668. doi: 10.1007/s00403-025-04176-0.
The aim of this meta-analysis was to determine the prevalence of sleep disorders among patients with atopic dermatitis (AD) and to explore the association between AD and sleep disorders. This meta-analysis was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and was prospectively registered in the International Prospective Systematic Review Registry (PROSPERO) database (registration number: CRD42024498045). Only English-written cross-sectional studies reporting the prevalence of sleep disorders in patients with AD were included in this analysis. We searched four databases: EMBASE, Web of Science, PubMed and the Cochrane Library as of 9 February 2025. Studies were screened using EndNote X9.1. Data were analyzed using STATA V15.0 software. Initially, a total of 861 studies were searched from databases. Ultimately, 32 studies including 85,921 participants were included in this meta-analysis. The prevalence of sleep disorders among individuals with AD was estimated using a random-effects model. The degree of heterogeneity was assessed by I statistic. If significant heterogeneity was detected, the source of heterogeneity was determined by meta-regression, and sensitivity analyses were then conducted by sequentially excluding each study to assess the robustness of the findings. This analysis revealed that the combined prevalence of sleep disorders among patients with AD was 43.4% (95% confidence interval: 39.7%-47.1%). Subgroup analyses were conducted according to region, data source, year of publication, severity of AD, sleep disorder assessment scales, classification of sleep problems, nocturnal awakenings, and number of days of sleep disorders experienced per week.
本荟萃分析的目的是确定特应性皮炎（AD）患者睡眠障碍的患病率，并探讨AD与睡眠障碍之间的关联。本荟萃分析按照系统评价和荟萃分析的首选报告项目（PRISMA）指南进行，并在国际前瞻性系统评价注册库（PROSPERO）数据库中进行了前瞻性注册（注册号：CRD42024498045）。本分析仅纳入了报告AD患者睡眠障碍患病率的英文横断面研究。截至2025年2月9日，我们检索了四个数据库：EMBASE、科学网、PubMed和Cochrane图书馆。使用EndNote X9.1对研究进行筛选。使用STATA V15.0软件进行数据分析。最初，从数据库中检索到总共861项研究。最终，本荟萃分析纳入了32项研究，共85921名参与者。使用随机效应模型估计AD患者睡眠障碍的患病率。通过I统计量评估异质性程度。如果检测到显著异质性，则通过Meta回归确定异质性来源，然后通过依次排除每项研究进行敏感性分析，以评估研究结果的稳健性。该分析显示，AD患者睡眠障碍的合并患病率为43.4%（95%置信区间：39.7%-47.1%）。根据地区、数据来源、发表年份、AD严重程度、睡眠障碍评估量表、睡眠问题分类、夜间觉醒次数以及每周经历睡眠障碍的天数进行亚组分析。
