Akelma Ahmet Zülfikar, Biten Aziz Alper
Pediatric Allergy and Immunology Unit, Ankara Kecioren Teaching and Research Hospital, Ankara, Turkey.
General Directorate of Management Services, Republic of Turkey Ministry of Health, Ankara, Turkey.
Pediatric Health Med Ther. 2015 Sep 28;6:147-151. doi: 10.2147/PHMT.S50476. eCollection 2015.
Pediatric eczema is a common disease which causes economic and social burden. Its incidence differs among the societies, with an incidence reported to reach up to 20% in developed countries. Eczema is the first allergic disease seen in the childhood, and it is recognized as a precursor for the development of atopic diseases such as asthma, allergic rhinitis, and food allergy in the forthcoming years of children. Increased incidence of eczema in recent years has led to new research in epidemiology, prevention, and intervention of this disease. It is no doubt important to treat itching, rash, and excoriation of the skin; however, treatment of pediatric eczema should not be considered only as a treatment of skin lesions. Considering skin treatment as the tip of the iceberg, proper management of the allergic processes can be accepted as the rest of the iceberg. The role of probiotics in the prevention of atopic eczema is yet to be clarified. Evidence presented by existing studies suggesting that probiotics may prevent pediatric eczema is not strong enough. A positive effect, if any, may be related with onset time, dose, duration, and use of specific probiotics. To date, there is no strong evidence for use of probiotics in the treatment of eczema; however, administration of probiotics in breast-feeding mothers in the prenatal period and in infants in the postnatal period can be accepted as a safe and helpful option in the prevention of eczema. Nevertheless, there are still questions to be answered in the future about probiotic administration for eczema. Clinical use of probiotics will gradually become more widespread when these questions are answered. Based on current information, the administration of probiotics for pediatric eczema topic is addressed in this review.
小儿湿疹是一种造成经济和社会负担的常见疾病。其发病率在不同社会群体中存在差异，据报道在发达国家发病率高达20%。湿疹是儿童期出现的首个过敏性疾病，并且被认为是儿童在未来几年发生诸如哮喘、过敏性鼻炎和食物过敏等特应性疾病的先兆。近年来湿疹发病率的增加引发了对该疾病流行病学、预防和干预方面的新研究。治疗皮肤瘙痒、皮疹和擦伤无疑很重要；然而，小儿湿疹的治疗不应仅被视为对皮肤损害的治疗。将皮肤治疗视为冰山一角，对过敏过程的恰当管理可被视为冰山的其余部分。益生菌在预防特应性湿疹中的作用尚待阐明。现有研究提供的表明益生菌可能预防小儿湿疹的证据并不充分。若有积极效果，可能与开始时间、剂量、持续时间以及特定益生菌的使用有关。迄今为止，尚无强有力的证据支持使用益生菌治疗湿疹；然而，在孕期对母乳喂养的母亲以及在产后对婴儿给予益生菌，可被视为预防湿疹的一种安全且有益的选择。尽管如此，关于益生菌用于湿疹治疗仍有一些问题有待未来解答。当这些问题得到解答时，益生菌的临床应用将逐渐变得更加广泛。基于当前信息，本综述探讨了益生菌用于小儿湿疹的问题。
