Division of Endocrinology and Metabolism and Duke Molecular Physiology Institute, Duke University Medical Center, Durham, North Carolina, USA.
Nutritional Epidemiology Program, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA.
J Clin Invest. 2018 Feb 1;128(2):545-555. doi: 10.1172/JCI96702.
Increased sugar consumption is increasingly considered to be a contributor to the worldwide epidemics of obesity and diabetes and their associated cardiometabolic risks. As a result of its unique metabolic properties, the fructose component of sugar may be particularly harmful. Diets high in fructose can rapidly produce all of the key features of the metabolic syndrome. Here we review the biology of fructose metabolism as well as potential mechanisms by which excessive fructose consumption may contribute to cardiometabolic disease.
高糖饮食被认为是导致全球肥胖和糖尿病流行及其相关心血管代谢风险的一个重要因素。由于果糖独特的代谢特性,其可能是造成这种危害的主要原因。高果糖饮食会迅速导致代谢综合征的所有关键特征。本文综述了果糖代谢的生物学特性,以及过量果糖摄入导致心血管代谢疾病的潜在机制。