Semenova-Kobzar' R A, Kushko L Ia, Iudin V M, Koval'chuk E V, Berezhnaia N M
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The use of two independent test-systems (intravenous adoptive transfer of immune response on tumour cells by intact syngenic recipient and mixed cultivation of immunocompetent and tumour cells in diffusion chambers) made it possible to establish that exogenous IL-2 possesses an expressive capacity both to the positive and to the negative modulation of immunological mechanisms during the tumour growth.
使用两种独立的测试系统(通过完整的同基因受体对肿瘤细胞进行免疫反应的静脉内过继转移,以及在扩散小室中对免疫活性细胞和肿瘤细胞进行混合培养),得以确定外源性白细胞介素-2在肿瘤生长过程中对免疫机制具有正向和负向调节的表达能力。