Kovbasiuk S A, Iudin V M, Kushko L Ia, Semenova-Kobzar' R A
Eksp Onkol. 1985;7(5):60-3.
The suppressor activity of the splenic cells in the cyclophosphamide (CP)-treated BALB/c mice with transplanted tumours was studied. CP was injected according to three different therapeutic effective schedules. The analysis of non-specific and antigen-specific tumour-associated suppressor activity in the splenic cell adoptive transfer system demonstrated that CP immunomodulating influence depends on the injection schedule. Usage of the most therapeutically effective CP injection schedule ensured a relative safety of the nonspecific tumour-associated suppressor activity and depression of the specific one.
研究了环磷酰胺（CP）处理的移植肿瘤BALB/c小鼠脾细胞的抑制活性。按照三种不同的治疗有效方案注射CP。在脾细胞过继转移系统中对非特异性和抗原特异性肿瘤相关抑制活性的分析表明，CP的免疫调节作用取决于注射方案。使用最具治疗效果的CP注射方案可确保非特异性肿瘤相关抑制活性的相对安全性，并抑制特异性抑制活性。
