中药治疗头颈部癌症患者放疗性口干症的系统评价。
A systematic review on Chinese herbal treatment for radiotherapy-induced xerostomia in head and neck cancer patients.
机构信息
Pharmacy Department, National Cancer Institute, Prescint 7, 62250 Putrajaya, Putrajaya, Malaysia; Traditional & Complementary Medicine (T&CM) Unit, National Cancer Institute, Prescint 7, 62250 Putrajaya, Putrajaya, Malaysia.
Traditional & Complementary Medicine (T&CM) Unit, National Cancer Institute, Prescint 7, 62250 Putrajaya, Putrajaya, Malaysia; First Clinical Medicine College, Jiangsu Province Hospital of Traditional Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, 138 Xianlin Road, 210023 Nanjing, Republic of China.
出版信息
Complement Ther Clin Pract. 2018 Feb;30:6-13. doi: 10.1016/j.ctcp.2017.10.004. Epub 2017 Oct 14.
BACKGROUND
Over 80% of head and neck cancer patients suffer from radiotherapy-induced xerostomia (dry mouth). Xerostomia affects cancer patients' quality of life, and xerostomia sometimes persists throughout the patients' lifetime. This review aimed to evaluate the effectiveness and safety of Chinese herbs in relieving radiotherapy induced xerostomia.
METHODS
Systematic searches were conducted on 6 databases (English and Chinese). Studies published up till May 2017 were considered for inclusion.
RESULTS
A final 14 RCTs (total 994 head and neck cancer patients undergoing radiotherapy) compared Chinese herbs with no herbs, were included in analysis. Very low to moderate quality of evidence found Chinese herbal treatment may relief radiotherapy-induced xerostomia and other related complications (such as oral mucositis and loss of appetite) in head and neck cancer patients.
CONCLUSION
There is limited evidence that Chinese herbal treatment may relief radiotherapy-induced xerostomia and other related complications in head and neck cancer patients.
背景
超过 80%的头颈部癌症患者患有放疗引起的口干症（口干）。口干影响癌症患者的生活质量，有时在患者的一生中都会持续存在。本综述旨在评估中药缓解放疗引起的口干的有效性和安全性。
方法
系统检索了 6 个数据库（英文和中文）。纳入了截止 2017 年 5 月发表的研究。
结果
最终纳入了 14 项 RCT（共 994 例头颈部癌症患者接受放疗），比较了中药与无药治疗，对纳入的研究进行了分析。发现低到中等质量的证据表明，中药治疗可能缓解头颈部癌症患者放疗引起的口干症及其他相关并发症（如口腔黏膜炎和食欲不振）。
结论
有有限的证据表明，中药治疗可能缓解头颈部癌症患者放疗引起的口干症及其他相关并发症。
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