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普瑞巴林用于带状疱疹后神经痛患者急性疼痛控制的疗效：一项荟萃分析。

The efficacy of pregabalin for acute pain control in herpetic neuralgia patients: A meta-analysis.

作者信息

Wang Suo-Liang, Wang Huan, Nie Hui-Yong, Bu Gang, Shen Xiao-Dong, Wang Hui

机构信息

Department of Rehabilitation Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shanxi Province, China.

出版信息

Medicine (Baltimore). 2017 Dec;96(51):e9167. doi: 10.1097/MD.0000000000009167.

DOI:10.1097/MD.0000000000009167
PMID:29390451
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5758153/
Abstract

OBJECTIVE

This meta-analysis aimed to illustrate the efficacy and safety of preganalin for pain management in patients with postherpetic neuralgia (PHN).

METHODS

In July 2017, a systematic computer-based search was conducted in PubMed, EMBASE, Web of Science, Cochrane Database of Systematic Reviews, and Google database. Data on patients with PHN that compared pregabalin versus placebo were retrieved. The endpoints were the visual analog scale (VAS) at 8 weeks, the percentage of 30% and 50% pain responders; sleep interference score and improvement in patient global impression of change (PGIC). After testing for publication bias and heterogeneity between studies, data were aggregated for random-effects models when necessary.

RESULTS

Seven clinical studies with 2192 patients (pregabalin group = 1381, control group = 811) were finally included in the meta-analysis. Pregabalin was associated with reduced pain scores at 8 weeks, corresponding to a reduction of 11.23 points (95% CI, -14.33, -8.13, P = .000) on a 100-point VAS. Pregabalin was also associated with a more percentage of 30% and 50% pain responders than controls (P < .05). Meanwhile, pregabalin can decrease sleep interference score and improvement in PGIC than control groups (P < .05).

CONCLUSIONS

Pregabalin was efficacious in the reduction of postoperative pain and improvement the sleep quality in patients with PHN.

摘要

目的

本荟萃分析旨在阐明普瑞巴林用于治疗带状疱疹后神经痛（PHN）患者疼痛的有效性和安全性。

方法

2017年7月，在PubMed、EMBASE、科学网、Cochrane系统评价数据库和谷歌数据库中进行了基于计算机的系统检索。检索了比较普瑞巴林与安慰剂治疗PHN患者的数据。终点指标为8周时的视觉模拟量表（VAS）、30%和50%疼痛缓解者的百分比、睡眠干扰评分以及患者总体变化印象改善情况（PGIC）。在检验研究间的发表偏倚和异质性后，必要时对数据进行随机效应模型汇总。

结果

本荟萃分析最终纳入了7项临床研究，共2192例患者（普瑞巴林组 = 1381例，对照组 = 811例）。普瑞巴林与8周时疼痛评分降低相关，在100分的VAS上相应降低11.23分（95%CI，-14.33，-8.13，P = 0.000）。与对照组相比，普瑞巴林治疗的30%和50%疼痛缓解者的比例也更高（P < 0.05）。同时，与对照组相比，普瑞巴林可降低睡眠干扰评分并改善PGIC（P < 0.05）。

结论

普瑞巴林在减轻PHN患者术后疼痛及改善睡眠质量方面有效。

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