Jin Shan-Shan, Song Wei-Juan
Department of Oncology Department of Laboratory Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Medicine (Baltimore). 2017 Dec;96(51):e9428. doi: 10.1097/MD.0000000000009428.
The multidrug resistance gene 1(MDR1) C3435T polymorphism has been reported to be associated with colorectal cancer (CRC) risk in Asians, however the results were inconsistent. Thus, we performed a meta-analysis to generate large-scale evidence on the association between C3435T polymorphism and CRC risk in Asian populations.
The PubMed, Web of Science, Embase, CNKI, and Chinese Biomedicine databases were searched up to January 15, 2017. The odd ratios (ORs) and 95% confidence intervals (95% CIs) were calculated by a fixed-effects or random-effects model. Sensitivity and cumulative meta-analysis were also performed.
A total of 7 studies involving 4818 individuals were included in this pooled-analysis. The results suggested that persons carrying a T allele at the C3435T polymorphism had a significantly decreased risk of CRC in Asian population (T vs C: OR = 0.897, 95%CI = 0.826-0.975, P = .01), and the significant association was also observed in another 2 genetic models (TT vs CC: OR = 0.721, 95%CI = 0.605-0.861, P < .001; TT vs TC+CC: OR = 0.679, 95%CI = 0.579-0.795, P < .001). Moreover, the results of sensitivity and cumulative meta-analysis indicated the stable of our results. Finally, funnel plot and Egger's test showed no evidence of publication bias.
In summary, this meta-analysis provided evidence that MDR1 C3435T polymorphism is associated with a decreased risk of CRC in Asian population.
多药耐药基因1（MDR1）C3435T多态性与亚洲人群的结直肠癌（CRC）风险相关，但结果并不一致。因此，我们进行了一项荟萃分析，以获取关于亚洲人群中C3435T多态性与CRC风险关联的大规模证据。
检索截至2017年1月15日的PubMed、Web of Science、Embase、CNKI和中国生物医学数据库。采用固定效应或随机效应模型计算比值比（OR）和95%置信区间（95%CI）。还进行了敏感性分析和累积荟萃分析。
本汇总分析共纳入7项研究，涉及4818名个体。结果表明，在亚洲人群中，C3435T多态性携带T等位基因的个体患CRC的风险显著降低（T vs C：OR = 0.897，95%CI = 0.826 - 0.975，P = 0.01），在另外两种遗传模型中也观察到显著关联（TT vs CC：OR = 0.721，95%CI = 0.605 - 0.861，P < 0.001；TT vs TC + CC：OR = 0.679，95%CI = 0.579 - 0.795，P < 0.001）。此外，敏感性分析和累积荟萃分析结果表明我们的结果具有稳定性。最后，漏斗图和Egger检验未显示发表偏倚的证据。
总之，这项荟萃分析提供了证据，表明MDR1 C3435T多态性与亚洲人群患CRC风险降低相关。
