肝纤维化
Liver fibrosis.
作者信息
Aydın M Merve, Akçalı Kamil Can
机构信息
Mikrogen Genetic Diagnostic Laboratory, Ankara, Turkey.
Department of Biophysics, Ankara University, School of Medicine, Ankara, Turkey.
出版信息
Turk J Gastroenterol. 2018 Jan;29(1):14-21. doi: 10.5152/tjg.2018.17330.
Abstract
Liver fibrosis is a wound-healing response generated against an insult to the liver that causes liver injury. It has the potential to progress into cirrhosis, and if not prevented, it may lead to liver cancer and liver failure. The activation of hepatic stellate cells (HSCs) is the central event underlying liver fibrosis. In addition to HSCs, numerous studies have supported the potential contribution of bone marrow-derived cells and myofibroblasts to liver fibrosis. The liver is a heterogeneous organ; thus, molecular and cellular events that underlie liver fibrogenesis are complex. This review aims to focus on major events that occur during liver fibrogenesis. In addition, important antifibrotic therapeutic approaches and experimental liver fibrosis models will be discussed.
摘要
肝纤维化是肝脏受到损伤性刺激后产生的一种伤口愈合反应。它有可能进展为肝硬化，如果不加以预防，可能会导致肝癌和肝衰竭。肝星状细胞（HSCs）的激活是肝纤维化的核心事件。除了肝星状细胞外，大量研究支持骨髓来源的细胞和成肌纤维细胞对肝纤维化的潜在作用。肝脏是一个异质性器官；因此，肝纤维化形成的分子和细胞事件很复杂。本综述旨在聚焦肝纤维化形成过程中发生的主要事件。此外，还将讨论重要的抗纤维化治疗方法和实验性肝纤维化模型。
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