Lefrancois L, Thomas M L, Bevan M J, Trowbridge I S
J Exp Med. 1986 May 1;163(5):1337-42. doi: 10.1084/jem.163.5.1337.
The leukocyte common antigen, T200, is expressed on all white blood cells but not on other differentiated cells. Within the hematopoietic lineage, specific cell types display characteristic structural forms of the molecule on their surface. We show that murine cytotoxic T lymphocyte clones and helper T cell clones contain different size mRNA for this molecule, and that the early precursors of T200 glycoprotein made in the helper and cytotoxic T cells differ in Mr. Thus, in addition to differences in posttranslational modifications, it is highly likely that a difference in protein structure contributes to the distinct forms of T200 glycoprotein found on these functional T cell subsets.
白细胞共同抗原T200在所有白细胞上表达，但在其他分化细胞上不表达。在造血谱系中，特定细胞类型在其表面呈现该分子的特征性结构形式。我们发现，小鼠细胞毒性T淋巴细胞克隆和辅助性T细胞克隆含有该分子不同大小的mRNA，并且辅助性T细胞和细胞毒性T细胞中产生的T200糖蛋白的早期前体在分子量上有所不同。因此，除了翻译后修饰的差异外，蛋白质结构的差异极有可能导致在这些功能性T细胞亚群上发现的T200糖蛋白的不同形式。
