Zheng Zhou-Ci, Wang Qing-Xuan, Zhang Wei, Zhang Xiao-Hua, Huang Du-Ping
Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.
Onco Targets Ther. 2018 Jan 11;11:307-311. doi: 10.2147/OTT.S154158. eCollection 2018.
In contrast to the excellent prognosis for papillary thyroid carcinoma (PTC), the high incidence of lymph node metastasis (LNM) markedly increases the risk of recurrence and secondary surgery. Thus, novel biomarkers must be urgently identified to assess LNM for patients with PTC. NCOA5 is deeply involved in the progression of human cancer; however, its role in thyroid cancer remains unknown.
Quantitative real-time polymerase chain reaction was conducted to investigate the expression of NCOA5 in PTC. RNA-seq data from The Cancer Genome Atlas (TCGA) database were downloaded to further understand the role of NCOA5 in PTC and its relationship with LNM.
NCOA5 was significantly downregulated in PTC tissues when compared with that in adjacent noncancerous thyroid tissues both in our local cohort and TCGA database. Reduced expression of NCOA5 was significantly associated with aggressive clinicopathological features, including histological type, tumor stage, BRAF-V600E mutation, LNM, extrathyroid extension, and clinical stage. Moreover, logistic analysis indicated that reduced expression of NCOA5, age, histological type, and clinical stage are independent high-risk factors for LNM in PTC.
Our study provides new insights and evidence that NOCA5 was significantly correlated with the progression of PTC and was particularly involved in LNM.
与甲状腺乳头状癌（PTC）良好的预后相反，淋巴结转移（LNM）的高发生率显著增加了复发和二次手术的风险。因此，迫切需要鉴定新的生物标志物来评估PTC患者的LNM情况。NCOA5深度参与人类癌症的进展；然而，其在甲状腺癌中的作用尚不清楚。
采用定量实时聚合酶链反应研究NCOA5在PTC中的表达。从癌症基因组图谱（TCGA）数据库下载RNA测序数据，以进一步了解NCOA5在PTC中的作用及其与LNM的关系。
在我们的本地队列和TCGA数据库中，与相邻的非癌甲状腺组织相比，PTC组织中NCOA5显著下调。NCOA5表达降低与侵袭性临床病理特征显著相关，包括组织学类型、肿瘤分期、BRAF-V600E突变、LNM、甲状腺外侵犯和临床分期。此外，逻辑分析表明，NCOA5表达降低、年龄、组织学类型和临床分期是PTC患者LNM的独立高危因素。
我们的研究提供了新的见解和证据，表明NOCA5与PTC的进展显著相关，尤其参与LNM过程。
