Bezeaud A, Drouet L, Leverger G, Griffin J H, Guillin M C
J Pediatr. 1986 May;108(5 Pt 1):698-701. doi: 10.1016/s0022-3476(86)81044-7.
Vitamin K-dependent proteins were measured sequentially by immunoassay in eight patients with acute lymphoblastic leukemia receiving L-asparaginase (1000 U/kg/day) for 10 days as induction therapy, in combination with vincristine or vindesine, daunorubicin, cyclophosphamide, and prednisone. The level of each protein was significantly decreased during L-asparaginase therapy, but both the time course of change and the severity of decrease differed among the proteins. The decrease in protein C, factor IX, and factor X was observed earlier than the decrease in protein S and factor II. In the first days of L-asparaginase therapy the protein C level was significantly lower than those of the other vitamin K-dependent proteins. The transient imbalance in the levels of plasma vitamin K-dependent proteins observed in the first days of treatment may contribute to the risk of thrombosis associated with L-asparaginase therapy.
对8例接受L-天冬酰胺酶（1000 U/kg/天）治疗10天作为诱导疗法的急性淋巴细胞白血病患者，采用免疫分析法依次测定维生素K依赖蛋白，这些患者同时接受长春新碱或长春地辛、柔红霉素、环磷酰胺和泼尼松治疗。在L-天冬酰胺酶治疗期间，每种蛋白的水平均显著降低，但各蛋白的变化时间进程和降低程度有所不同。蛋白C、因子IX和因子X的降低比蛋白S和因子II的降低出现得更早。在L-天冬酰胺酶治疗的最初几天，蛋白C水平显著低于其他维生素K依赖蛋白。治疗最初几天观察到的血浆维生素K依赖蛋白水平的短暂失衡可能会增加与L-天冬酰胺酶治疗相关的血栓形成风险。
