Paramelle B, Vila A, Pollak P, Muller P, Gavelle D, Reymond F, Brambilla C, Stoebner P
Presse Med. 1986 Mar 22;15(12):563-7.
In a prospective study 43 patients with chronic obstructive lung disease and severe respiratory insufficiency were systematically investigated for polyneuropathy, although they had no risk factor of that disease. Electrophysiological recordings showed slight or significant signs of polyneuropathy in 17 and 15 patients respectively, thus indicating that the condition is frequent. Clinically, it was often silent or manifested only by sensory disorders predominant in the lower limbs. Electrophysiology suggested axonal degeneration associated with some degree of demyelinization, and these lesions were found at histology to be present in sensory nerves. Histological examination of the muscles showed peripheral mixed neurogenic atrophy probably due to hypoxia. Major thickening of basal material was observed in capillaries of the endomysium and endoneurium. Statistical analysis of clinical parameters and respiratory function values in relation to the presence and importance of polyneuropathy showed that the only significant difference was the longer duration of hypoxia in patients with nerve involvement. Age, alcoholism and the other respiratory function values did not seem to be correlated with lesions of the peripheral nervous system.
在一项前瞻性研究中，对43例慢性阻塞性肺疾病且伴有严重呼吸功能不全的患者进行了系统性多神经病调查，尽管他们并无该疾病的风险因素。电生理记录显示，分别有17例和15例患者存在轻微或明显的多神经病体征，这表明该病症很常见。临床上，其常常无症状或仅表现为以下肢为主的感觉障碍。电生理学提示轴突变性伴有一定程度的脱髓鞘，组织学检查发现这些病变存在于感觉神经中。肌肉组织学检查显示可能由于缺氧导致周围混合性神经源性萎缩。在内膜和神经内膜的毛细血管中观察到基底物质明显增厚。对与多神经病的存在及严重程度相关的临床参数和呼吸功能值进行统计分析表明，唯一显著的差异是神经受累患者的缺氧持续时间更长。年龄、酗酒及其他呼吸功能值似乎与周围神经系统病变无关。
