Pfeiffer G, Kunze K, Brüch M, Kutzner M, Ladurner G, Malin J P, Tackmann W
Department of Neurology, Universitätsklinik Hamburg Eppendorf, Federal Republic of Germany.
J Neurol. 1990 Jul;237(4):230-3. doi: 10.1007/BF00314624.
The prevalence of clinical and electrophysiological signs of peripheral nerve disease was evaluated in 151 patients with chronic obstructive pulmonary disease. Patients with concomitant disorders affecting the peripheral nervous system were excluded. Thirty patients had clinical signs of a mild sensorimotor and distal neuropathy and 13 additional patients had only electrophysiological abnormalities. The rate and the severity of the neuropathy correlated with the severity of chronic hypoxaemia. Three out of 20 patients with mild hypoxaemia (PaO2 less than 15 mm Hg below normal) had polyneuropathy as compared with 15 out of 36 with severe hypoxaemia (PaO2 more than 30 mm Hg below normal (rates different at the 10% level)). PaO2 and age were the only variables discriminating between patients with and without peripheral neuropathy.
在151例慢性阻塞性肺疾病患者中评估了周围神经疾病的临床和电生理体征的患病率。排除了伴有影响周围神经系统疾病的患者。30例患者有轻度感觉运动和远端神经病变的临床体征，另外13例患者仅有电生理异常。神经病变的发生率和严重程度与慢性低氧血症的严重程度相关。20例轻度低氧血症（动脉血氧分压低于正常15mmHg以下）患者中有3例发生多发性神经病变，而36例严重低氧血症（动脉血氧分压低于正常30mmHg以上）患者中有15例发生（发生率在10%水平有差异）。动脉血氧分压和年龄是区分有无周围神经病变患者的唯一变量。
