Kameyama Hitoshi, Shimada Yoshifumi, Yagi Ryoma, Yamada Saki, Hotta Shinnosuke, Tajima Yosuke, Nakano Mae, Okamura Takuma, Nakano Masato, Ichikawa Hiroshi, Hanyu Takaaki, Nagahashi Masayuki, Sakata Jun, Kobayashi Takashi, Wakai Toshifumi
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences.
Gan To Kagaku Ryoho. 2017 Nov;44(12):1083-1085.
This study aimed to evaluate the health-related quality of life(QOL)using EQ-5D-5L scores for patients who underwent surgery for colorectal cancer. A total of 30 consecutive patients(14 men and 16 women; median age: 67.5 years)from the outpatient clinic of our institute in January 2017 were eligible for this study. The primary tumor was located in the colon(n= 18)or rectum/anu(s n=12). Twelve patient(s 40.0%)had cancer recurrence, and 3 patient(s 10.0%)had a stoma. In addition, 11 patients(36.7%)underwent chemotherapy. The median EQ-5D-5L score for all the patients was 0.867(range, 0.324- 1.000). The EQ-5D-5L score of patients with recurrence was significantly lower(0.820)than that of patients without recurrence( 0.948)(p=0.002). Furthermore, the EQ-5D-5L score of women(0.834)was significantly lower than that of men (0.942)(p=0.015). No significant difference was noted between the EQ-5D-5L score and other factors, such as age, cancer stage, location of primary tumor, absence/presence of chemotherapy, and absence/presence of stoma. In conclusion, using EQ-5D-5L scores, female gender and cancer recurrence were found to be associated with low QOL of patients after surgery for colorectal cancer.
本研究旨在使用EQ-5D-5L评分评估接受结直肠癌手术患者的健康相关生活质量(QOL)。2017年1月,我们研究所门诊连续共有30例患者(14例男性和16例女性;中位年龄:67.5岁)符合本研究条件。原发肿瘤位于结肠(n = 18)或直肠/肛门(n = 12)。12例患者(40.0%)发生癌症复发,3例患者(10.0%)有造口。此外,11例患者(36.7%)接受了化疗。所有患者的EQ-5D-5L评分中位数为0.867(范围:0.324 - 1.000)。复发患者的EQ-5D-5L评分(0.820)显著低于未复发患者(0.948)(p = 0.002)。此外,女性的EQ-5D-5L评分(0.834)显著低于男性(0.942)(p = 0.015)。EQ-5D-5L评分与年龄、癌症分期、原发肿瘤位置、是否接受化疗以及是否有造口等其他因素之间未发现显著差异。总之,使用EQ-5D-5L评分发现,女性性别和癌症复发与结直肠癌手术后患者的低生活质量相关。