Molecular Mycology Research Laboratory, Centre for Infectious Diseases and Microbiology, Westmead Clinical School-Sydney Medical School, Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, Sydney, NSW, Australia; Westmead Institute for Medical Research, Westmead, NSW, Australia.
Molecular Mycology Research Laboratory, Centre for Infectious Diseases and Microbiology, Westmead Clinical School-Sydney Medical School, Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, Sydney, NSW, Australia; Westmead Institute for Medical Research, Westmead, NSW, Australia.
Trends Parasitol. 2018 Apr;34(4):322-334. doi: 10.1016/j.pt.2018.01.001. Epub 2018 Jan 24.
Molecular surveillance of antimalarial drug resistance markers has become an important part of resistance detection and containment. In the current climate of multidrug resistance, including resistance to the global front-line drug artemisinin, there is a consensus to upscale molecular surveillance. The most salient limitation to current surveillance efforts is that skill and infrastructure requirements preclude many regions. This includes sub-Saharan Africa, where Plasmodium falciparum is responsible for most of the global malaria disease burden. New molecular and data technologies have emerged with an emphasis on accessibility. These may allow surveillance to be conducted in broad settings where it is most needed, including at the primary healthcare level in endemic countries, and extending to the village health worker.
抗疟药耐药性标志物的分子监测已成为耐药性检测和遏制的重要组成部分。在当前多种药物耐药性的情况下，包括对全球一线药物青蒿素的耐药性，人们普遍认为需要扩大分子监测范围。当前监测工作的最突出限制是，技能和基础设施要求排除了许多地区。这包括撒哈拉以南非洲，那里恶性疟原虫是全球疟疾疾病负担的主要原因。新的分子和数据技术已经出现，重点是可及性。这些技术可能允许在最需要的广泛环境中进行监测，包括在流行国家的初级保健水平，并扩展到乡村卫生工作者。
