Department of Radiology, the 2nd Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Department of Radiology, the 2nd Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Obes Res Clin Pract. 2018 Nov-Dec;12(6):555-561. doi: 10.1016/j.orcp.2018.01.003. Epub 2018 Feb 12.
There is a growing literature documenting a variety of brain abnormalities associated with obesity. However, little is known about the effects of obesity on inter-hemispheric connectivity in aging people.
Participants included 61 cognitively intact elderly (including people with obesity, overweight, and lean controls) who underwent structural MRI, resting-state functional magnetic resonance imaging (rsfMRI) and standard neuropsychological batteries. Techniques including FreeSurfer and Voxel-mirrored Homotopic Connectivity (VMHC) were employed to evaluate inter-hemispheric structural and functional connectivity respectively.
There were no differences of cognitive abilities and vascular risks among groups. When compared to lean controls, obese group had greater VMHC in fusiform gyrus (FG); while overweight group had greater VMHC in FG, calcarine gyrus, inferior temporal gyrus (ITG), and postcentral gyrus (PCG). Moreover, the obesity group had lower VMHC in calcarine gyrus and PCG than overweight group (p<0.05, corrected).
The present study suggested, increased inter-hemispheric information transmission in networks supporting visual and sensorimotor function may lead to gain in weight, by possibly mediating diet behaviours of individuals.
越来越多的文献记录了与肥胖相关的各种大脑异常。然而，对于肥胖对老年人大脑半球间连通性的影响知之甚少。
参与者包括 61 名认知正常的老年人（包括肥胖、超重和正常体重的对照组），他们接受了结构磁共振成像、静息态功能磁共振成像（rsfMRI）和标准神经心理学测试。使用 FreeSurfer 和 Voxel-mirrored Homotopic Connectivity (VMHC) 等技术分别评估大脑半球间的结构和功能连通性。
各组之间的认知能力和血管风险无差异。与正常体重对照组相比，肥胖组在梭状回（FG）的 VMHC 较高；而超重组在 FG、距状回、颞下回（ITG）和后中央回（PCG）的 VMHC 较高。此外，肥胖组的距状回和 PCG 的 VMHC 低于超重组（p<0.05，校正）。
本研究表明，支持视觉和感觉运动功能的网络中大脑半球间信息传递的增加，可能通过调节个体的饮食行为导致体重增加。
