Roos R A, Bots G T, Hermans J
Acta Neurol Scand. 1986 Feb;73(2):131-5. doi: 10.1111/j.1600-0404.1986.tb03253.x.
In an electron microscopic study neuronal nuclear membrane indentations and astrocyte/neuron ratios in the nucleus accumbens, caudate nucleus and frontal cortex were counted in 30 Huntington's disease patients and 23 controls. Discriminant analysis was performed and resulted in a discriminant equation, which was able to recognize all controls correctly. Three Huntington patients were not correctly recognized, although in only one patient the probability of being a control was higher than being a Huntington patient. This discriminant equation was used in four choreatic patients with a negative family history. Two patients were indicated as controls, one patient as being a Huntington patient, and one as dubious. The diagnostic yield of discriminant analysis is discussed.
在一项电子显微镜研究中，对30例亨廷顿舞蹈症患者和23名对照者的伏隔核、尾状核及额叶皮质中的神经元核膜压迹和星形胶质细胞/神经元比例进行了计数。进行了判别分析，得出了一个判别方程，该方程能够正确识别所有对照者。有3例亨廷顿患者未被正确识别，尽管只有1例患者被判定为对照者的概率高于被判定为亨廷顿患者的概率。该判别方程用于4例家族史阴性的舞蹈症患者。2例患者被判定为对照者，1例患者被判定为亨廷顿患者，1例结果存疑。文中讨论了判别分析的诊断价值。
