Roos R A, Bots G T
J Neurol Sci. 1983 Sep;61(1):37-47. doi: 10.1016/0022-510x(83)90053-9.
Electron-microscopical examination of the nucleus accumbens, caudate nucleus and frontal cortex was performed in 21 patients with Huntington's disease (HD) and 21 age-matched controls. In HD, nuclear membrane indentations (NMI) were found in 25%, 29% and 20%, respectively, of the neurons of these areas. In the control group these figures were 4%, 4% and 38%, respectively. Possible pathogenetic mechanisms of the NMI are discussed.
对21例亨廷顿舞蹈症（HD）患者和21例年龄匹配的对照者的伏隔核、尾状核和额叶皮质进行了电子显微镜检查。在HD患者中，这些区域的神经元中分别有25%、29%和20%发现了核膜凹陷（NMI）。在对照组中，这些数字分别为4%、4%和38%。本文讨论了NMI可能的发病机制。
