Department of Chemistry, Jinan University, Guangzhou, 510632, P.R. China.
Chem Asian J. 2018 Apr 16;13(8):996-1004. doi: 10.1002/asia.201800048. Epub 2018 Mar 13.
A combination of chemo- and photothermal therapy has emerged as a promising tactic for cancer therapy. However, the intricacy of accurate delivery and the ability to initiate drug release in specific tumor sites remains a challenging puzzle. Hence, to assure that the chemotherapeutic drug and photothermal agent are synchronously delivered to a tumor area for their synergistic effect, dual-target (RC-12 and PG-6 peptides) functionalized selenium nanoparticles loaded with both doxorubicin (DOX) and indocyanine green (ICG) were designed and successfully synthesized. The as-synthesized nanoparticles exhibited good monodispersity, size stability, and consistent spectral characteristics compared with those of ICG or DOX alone. The nanoparticles underwent self-immolated cleavage under irradiation from a near-IR laser and released the loaded drug owing to sufficient hyperthermia. Moreover, the internalized nanoparticles triggered the overproduction of intracellular reactive oxygen species to induce cell apoptosis. Taken together, this study provides a sequentially triggered nanosystem to achieve precise drug delivery by chemo-photothermal combination.
化疗和光热疗法的联合已成为癌症治疗中一种很有前途的策略。然而，精确传递的复杂性和在特定肿瘤部位启动药物释放的能力仍然是一个具有挑战性的难题。因此，为了确保化疗药物和光热剂同时递送到肿瘤区域以发挥协同作用，设计并成功合成了负载多柔比星（DOX）和吲哚菁绿（ICG）的双靶向（RC-12 和 PG-6 肽）功能化硒纳米粒子。与单独的 ICG 或 DOX 相比，所合成的纳米粒子具有良好的单分散性、尺寸稳定性和一致的光谱特性。纳米粒子在近红外激光照射下发生自燃烧裂解，并由于足够的热疗释放负载的药物。此外，内化的纳米粒子引发细胞内活性氧的过度产生，诱导细胞凋亡。总的来说，这项研究提供了一种顺序触发的纳米系统，通过化疗-光热联合实现精确的药物传递。
