Departments of Neuroscience, Psychiatry & Pharmacology, Columbia University, New York, NY, USA; Division of Integrative Neuroscience, Department of Psychiatry, New York State Psychiatric Institute, New York, NY, USA.
Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA.
Neuron. 2018 Feb 7;97(3):670-683.e6. doi: 10.1016/j.neuron.2018.01.016. Epub 2018 Jan 31.
The hippocampus is traditionally thought to transmit contextual information to limbic structures where it acquires valence. Using freely moving calcium imaging and optogenetics, we show that while the dorsal CA1 subregion of the hippocampus is enriched in place cells, ventral CA1 (vCA1) is enriched in anxiety cells that are activated by anxiogenic environments and required for avoidance behavior. Imaging cells defined by their projection target revealed that anxiety cells were enriched in the vCA1 population projecting to the lateral hypothalamic area (LHA) but not to the basal amygdala (BA). Consistent with this selectivity, optogenetic activation of vCA1 terminals in LHA but not BA increased anxiety and avoidance, while activation of terminals in BA but not LHA impaired contextual fear memory. Thus, the hippocampus encodes not only neutral but also valence-related contextual information, and the vCA1-LHA pathway is a direct route by which the hippocampus can rapidly influence innate anxiety behavior.
传统观点认为，海马体将情境信息传递到边缘结构，在那里获得情绪价值。我们使用自由移动的钙成像和光遗传学技术表明，虽然海马体的背侧 CA1 亚区富含位置细胞，但腹侧 CA1（vCA1）富含焦虑细胞，这些细胞被焦虑环境激活，并且是回避行为所必需的。通过其投射目标来成像细胞表明，焦虑细胞在投射到下丘脑外侧区（LHA）的 vCA1 群体中富集，而不在基底杏仁核（BA）中富集。与这种选择性一致，LHA 中的 vCA1 末梢的光遗传学激活会增加焦虑和回避，而 BA 中的末梢的激活会损害情境恐惧记忆。因此，海马体不仅编码中性信息，还编码与情绪相关的情境信息，而 vCA1-LHA 通路是海马体可以快速影响先天焦虑行为的直接途径。
