系统性硬化症患者的神经性疼痛：一项横断面研究。
Neuropathic pain in Systemic Sclerosis patients: A cross-sectional study.
作者信息
Sousa-Neves Joana, Cerqueira Marcos, Santos-Faria Daniela, Afonso Carmo, Teixeira Filipa
机构信息
Rheumatology Department, Conde de Bertiandos Hospital, Ponte de Lima, Portugal.
Rheumatology Department, Conde de Bertiandos Hospital, Ponte de Lima, Portugal.
出版信息
Reumatol Clin (Engl Ed). 2019 Nov-Dec;15(6):e99-e101. doi: 10.1016/j.reuma.2017.12.010. Epub 2018 Feb 1.
OBJECTIVES
To investigate if patients with Systemic Sclerosis (SSc) show a higher prevalence of neuropathic pain (NP) in comparison with controls. To study the relationship between clinical variables of the disease and NP among SSc patients.
MATERIAL AND METHODS
48 patients and 45 controls were included. Presence of NP was assessed applying the DN4 "Douleur Neuropathique en 4 Questions" questionnaire. Different clinical variables were also assessed in patients. Statistical analysis included parametric, nonparametric tests and multivariate logistic regression.
RESULTS
NP was significantly higher in SSc patients (56.2% vs 13.3%, p<0.001). Mean Modified Rodnan Skin Score was independently associated with the presence of NP (p<0.05, OR 1.90).
CONCLUSIONS
Peripheral nervous system involvement in SSc is not well studied and, as far as the authors are aware, this is the first study published evaluating NP in SSc patients and controls. These findings should raise the awareness of the clinician to recognize and address the presence of NP in these patients, especially in those with severe skin involvement.
目的
调查系统性硬化症（SSc）患者与对照组相比，神经性疼痛（NP）的患病率是否更高。研究SSc患者中疾病临床变量与NP之间的关系。
材料与方法
纳入48例患者和45例对照。应用DN4“四问神经性疼痛”问卷评估NP的存在情况。还对患者的不同临床变量进行了评估。统计分析包括参数检验、非参数检验和多因素逻辑回归。
结果
SSc患者中NP的发生率显著更高（56.2%对13.3%，p<0.001）。平均改良Rodnan皮肤评分与NP的存在独立相关（p<0.05，OR 1.90）。
结论
SSc患者外周神经系统受累情况尚未得到充分研究，据作者所知，这是首篇发表的评估SSc患者和对照中NP的研究。这些发现应提高临床医生对这些患者中NP存在情况的认识并加以处理，尤其是那些皮肤受累严重的患者。
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