Aix Marseille Univ, CNRS, INSERM, CIML, Marseille, France.
Aix Marseille Univ, CNRS, INSERM, CIML, Marseille, France.
Cell Immunol. 2018 Aug;330:168-174. doi: 10.1016/j.cellimm.2018.01.010. Epub 2018 Feb 15.
Lymph nodes (LN) are secondary lymphoid organs dispersed throughout the body that filter lymph and assist the immune system in mounting immune responses. These functions are supported by a complex stromal microarchitecture composed of mesenchymal and vascular elements. Different subsets of macrophages (MΦ) reside in the LN and are endowed with immune and trophic functions. Here we review these different subsets with particular emphasis on the recently described T cell zone MΦ. We also address the potential crosstalk between LN stromal cells and MΦ, proposing that the former constitute niches for the latter by supplying factors required for their specification, survival and turnover. In turn, MΦ could inform their stromal partners about the immune status of the LN and orchestrate the remodelling of its microanatomy during immune responses.
淋巴结（LN）是散布在全身的次级淋巴器官，可过滤淋巴并协助免疫系统引发免疫反应。这些功能由一个由间充质和血管成分组成的复杂基质微结构支持。不同亚群的巨噬细胞（MΦ）存在于 LN 中，并具有免疫和营养功能。在这里，我们特别强调最近描述的 T 细胞区巨噬细胞，对这些不同的亚群进行综述。我们还探讨了 LN 基质细胞和 MΦ 之间潜在的串扰，提出前者通过提供其特化、存活和更替所需的因子构成后者的龛位。反过来，MΦ 可以告知其基质伙伴 LN 的免疫状态，并在免疫反应过程中协调其微解剖结构的重塑。
