Laboratory of Healthcare Research and Pharmacoepidemiology, Unit of Biostatistics, Epidemiology and Public Health, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, Via Bicocca degli Arcimboldi 8, 20126 Milan, Italy.
Laboratory of Healthcare Research and Pharmacoepidemiology, Unit of Biostatistics, Epidemiology and Public Health, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, Via Bicocca degli Arcimboldi 8, 20126 Milan, Italy.
Semin Arthritis Rheum. 2018 Aug;48(1):28-34. doi: 10.1016/j.semarthrit.2018.01.003. Epub 2018 Jan 6.
Psoriatic arthritis (PsA) is a specific form of inflammatory arthritis associated with psoriasis affecting in the same measure men and women but with a consistent geographic variability. Since the burden of PsA frequency has important implications in the definition of the healthcare policies, it is important to measure the frequency of disease in the general population.
To quantify the global health burden of PsA summarizing the data provided by the population-based available studies investigating prevalence and incidence of the disease.
A MEDLINE search was performed to identify all studies reporting the prevalence or incidence of PsA. Fixed- and random-effect models were fitted to estimate the prevalence and incidence pooled estimates. Between-study heterogeneity was evaluated using the Q statistic and the I index and Publication bias using Egger's asymmetry test.
Twenty-eight studies were included in the meta-analysis, 17 retrieved from the literature search and 11 from the meta-analysis of Alamanos et al. The random effect pooled PsA prevalence and incidence rates are respectively 133 every 100,000 subjects (95% CI, 107-164 every 100,000 subjects) and 83 every 100,000 PY (95% CI, 41-167 every 100,000 PY). High between-study heterogeneity was found for both prevalence and incidence estimates.
This study allowed the estimation of a global average prevalence and incidence rates of PsA and the evaluation of the geographic variability. The high between-study heterogeneity suggests the importance to look not only at the pooled estimates but also at the study-specific estimate.
银屑病关节炎（PsA）是一种与银屑病相关的特定形式的炎症性关节炎，同样影响男性和女性，但具有一致的地域差异。由于 PsA 频率的负担对医疗保健政策的定义有重要影响，因此衡量普通人群中疾病的频率很重要。
通过总结基于人群的现有研究中调查疾病患病率和发病率的数据，量化 PsA 的全球健康负担。
进行了 MEDLINE 搜索，以确定所有报告 PsA 患病率或发病率的研究。使用固定效应和随机效应模型拟合来估计患病率和发病率的汇总估计值。使用 Q 统计量和 I 指数评估研究间异质性，使用 Egger 不对称检验评估发表偏倚。
共有 28 项研究纳入荟萃分析，其中 17 项来自文献检索，11 项来自 Alamanos 等人的荟萃分析。随机效应汇总的 PsA 患病率和发病率分别为每 10 万人 133 例（95%CI，每 10 万人 107-164 例）和每 10 万人 83 例 PY（95%CI，每 10 万人 41-167 例 PY）。患病率和发病率估计均存在较高的研究间异质性。
本研究允许估计全球平均的 PsA 患病率和发病率，并评估地理变异。较高的研究间异质性表明，不仅要关注汇总估计值，还要关注特定研究的估计值。
