Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Departments of Neuroscience and Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Neurobiol Learn Mem. 2019 Nov;165:106791. doi: 10.1016/j.nlm.2018.01.012. Epub 2018 Jan 31.
The ubiquitin proteasome system (UPS) is a highly conserved pathway that tightly regulates protein turnover in cells. This process is integral to neuronal development, differentiation, and function. Several members of the UPS are disrupted in neuropsychiatric disorders, highlighting the importance of this pathway in brain development and function. In this review, we discuss some of these pathway members, the molecular processes they regulate, and the potential for targeting the UPS in an effort to develop therapeutic strategies in neuropsychiatric and neurodevelopmental disorders.
泛素蛋白酶体系统（UPS）是一种高度保守的途径，可严密调控细胞内蛋白质的周转率。这一过程对神经元的发育、分化和功能至关重要。神经精神疾病中 UPS 的几个成员被破坏，突显了该途径在大脑发育和功能中的重要性。在这篇综述中，我们讨论了其中的一些途径成员、它们调控的分子过程，以及靶向 UPS 以努力开发神经精神和神经发育障碍治疗策略的潜力。
