Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si, Korea.
Balkan Med J. 2018 Jan 20;35(1):101-104. doi: 10.4274/balkanmedj.2017.0322.
Serrated polyposis syndrome is a disease that is often missed in the clinical setting and is associated with colorectal cancer. We investigated the prevalence of SPS and the association between colorectal or other cancers in a 10-year, retrospective data analysis.
We reviewed complete colonoscopy data obtained from January 2005 through January 2015 at a health-screening centre. Serrated polyposis syndrome was defined on the basis of the criteria established by the 2010 World Health Organization.
Of a total of 53.842 consecutive subjects who underwent complete colonoscopy, 12 (0.022%) patients had serrated polyposis syndrome. All of these cases were under-recognized by the endoscopist or referring physician. The mean patient age was 58.6 years; 67% of the patients were men and 33% were women. No serrated polyposis syndrome patients had a first-degree relative with serrated polyposis syndrome, and no serrated polyposis syndrome patients had colorectal cancer. Two cases (17%) had extra-colonic cancers (prostate cancer and thyroid cancer). Eight cases (67%) had a family history of cancer (stomach, breast, lung, pancreas, prostate and colorectal cancer).
Serrated polyposis syndrome was a rare condition in a 10-year database, and it was diagnosed late in all cases. Serrated polyposis syndrome may be associated with an increased risk of extra-colonic cancer.
锯齿状息肉综合征是一种在临床环境中经常被忽视的疾病，与结直肠癌有关。我们通过一项为期 10 年的回顾性数据分析，调查锯齿状息肉综合征的流行情况以及其与结直肠或其他癌症之间的关联。
我们回顾了 2005 年 1 月至 2015 年 1 月在健康筛查中心进行的完整结肠镜检查数据。锯齿状息肉综合征是根据 2010 年世界卫生组织制定的标准定义的。
在总共 53842 例连续接受完整结肠镜检查的患者中，有 12 例（0.022%）患者患有锯齿状息肉综合征。所有这些病例均被内镜医生或转诊医生漏诊。患者的平均年龄为 58.6 岁；67%的患者为男性，33%为女性。没有锯齿状息肉综合征患者的一级亲属患有锯齿状息肉综合征，也没有锯齿状息肉综合征患者患有结直肠癌。有 2 例（17%）患者患有结外癌症（前列腺癌和甲状腺癌）。有 8 例（67%）患者有癌症家族史（胃、乳腺、肺、胰腺、前列腺和结直肠癌）。
在 10 年的数据库中，锯齿状息肉综合征是一种罕见的疾病，所有病例均诊断较晚。锯齿状息肉综合征可能与结外癌症的风险增加有关。
