Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China , Qingdao 266003, P. R. China.
Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology , Qingdao, 266237, P. R. China.
Org Lett. 2018 Feb 16;20(4):1138-1141. doi: 10.1021/acs.orglett.8b00061. Epub 2018 Feb 5.
A new indole alkaloid, named taichunamide H (1), was obtained from cultures of the fungus Aspergillus versicolor. With observation of a carbon resonance with a chemical shift of 190.4 ppm, generally thought to be a carbonyl, the structure of 1 was initially proposed to be a diastereomer of taichunamide A that contains a unique spiro-azetidine moiety. Further analysis of compound 1 using X-ray diffraction showed that the spiro-azetidine moiety should be revised as a fused-imine-containing pyrrole ring, with the resonance at 190.4 ppm assigned as an imine carbon. Accordingly, the structure of taichunamide A was also revised.
从真菌黄曲霉的培养物中获得了一种新的吲哚生物碱，命名为 taichunamide H（1）。观察到一个碳的共振，化学位移为 190.4 ppm，通常被认为是一个羰基，因此 1 的结构最初被提议为含有独特的螺-氮杂环丁烷部分的 taichunamide A 的非对映异构体。使用 X 射线衍射进一步分析化合物 1 表明，螺-氮杂环丁烷部分应修正为含有稠合亚胺的吡咯环，共振在 190.4 ppm 处分配为亚胺碳。相应地，taichunamide A 的结构也进行了修订。
