Kai Aika, Kato Hikaru, Sherman David H, Williams Robert M, Tsukamoto Sachiko
Graduate School of Pharmaceutical Sciences, Kumamoto University, Oe-honmachi 5-1, Kumamoto 862-0973, Kumamoto, Japan.
Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States.
Tetrahedron Lett. 2018 Nov 28;50(48):4236-4240. doi: 10.1016/j.tetlet.2018.10.034. Epub 2018 Oct 20.
A new prenylated indoxyl alkaloid, Amoenamide B (), was isolated from NRRL 35600 along with Asperochramide A (). Although many prenylated oxyindole alkaloids, containing bicyclo[2.2.2]diazaoctane cores, have been isolated from the fungus of the genera and to date, is the fourth compound with the indoxyl unit containing the cores. During the structure elucidation of , we found that the planar structure matched to that of Speramide A (), isolated from KM007, but the reported structure of was incorrect and turned out to be that of Taichunamide H (), recently isolated from HDN11-84.
从NRRL 35600中分离出一种新的异戊烯基吲哚生物碱，Amoenamide B（），同时还分离出了Asperochramide A（）。尽管迄今为止已从多个属的真菌中分离出许多含有双环[2.2.2]二氮杂辛烷核心的异戊烯基氧化吲哚生物碱，但 是第四个含有该核心的吲哚单元的化合物。在对 的结构解析过程中，我们发现其平面结构与从KM007中分离出的Speramide A（）的平面结构相匹配，但报道的 的结构是错误的，结果证明它是最近从HDN11-84中分离出的Taichunamide H（）的结构。
