Institut für Organische Chemie, Albert-Ludwigs-Universität Freiburg , Albertstrasse 21, 79104 Freiburg im Breisgau, Germany.
Org Lett. 2018 Feb 16;20(4):1066-1069. doi: 10.1021/acs.orglett.7b04035. Epub 2018 Feb 5.
A rhodium-catalyzed chemo-, regio-, and enantioselective intermolecular decarboxylative alkynylation of terminal allenes with arylpropiolic acids is reported. Employing a Rh(I)/(R)-Tol-BINAP catalytic system, branched allylic 1,4-enynes were obtained under mild conditions. The overall utility of this protocol is exemplified by a broad functional group compatibility.
报道了铑催化的末端炔丙酸与芳基丙二腈的化学选择性、区域选择性和对映选择性的分子间脱羧炔基化反应。在 Rh(I)/(R)-Tol-BINAP 催化体系的作用下，在温和条件下得到支链烯丙基 1,4-烯炔。该反应具有广泛的官能团兼容性，充分体现了该方法的实用性。
