Sparkes R S, Sparkes M C, Bass H N
Cytogenet Cell Genet. 1986;41(4):250-2. doi: 10.1159/000132238.
Chromosomal and gene marker studies of somatic cells in a family with multiple chromosome translocations show apparent instability of the translocations in transmission from generation to generation. This instability is attributed to meiotic crossing-over between the involved chromosomes. Technical advances in chromosome analysis combined with human gene map information in the study of this unusual family demonstrate for the first time that crossing-over involves exchange of chromatin between nonsister chromatids of homologous chromosomes.
对一个有多条染色体易位的家族中的体细胞进行的染色体和基因标记研究表明，这些易位在世代传递中表现出明显的不稳定性。这种不稳定性归因于相关染色体之间的减数分裂交叉。染色体分析技术的进步与该特殊家族研究中的人类基因图谱信息相结合，首次证明交叉涉及同源染色体非姐妹染色单体之间的染色质交换。
