从一种源自海洋藻类的链霉菌属物种的多样性增强提取物中获得的具有群体感应抑制活性的新型α-吡啶酮。
New α-Pyridones with Quorum-Sensing Inhibitory Activity from Diversity-Enhanced Extracts of a Streptomyces sp. Derived from Marine Algae.
作者信息
Du Yuqi, Sun Jian, Gong Qianhong, Wang Yi, Fu Peng, Zhu Weiming
机构信息
Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China , Qingdao 266003, China.
Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology , Qingdao 266003, China.
出版信息
J Agric Food Chem. 2018 Feb 28;66(8):1807-1812. doi: 10.1021/acs.jafc.7b05330. Epub 2018 Feb 13.
Four new α-pyrones (1-4) and eight known analogues (5-12) were identified from the secondary metabolites of Streptomyces sp. OUCMDZ-3436 derived from the marine green algae Enteromorpha prolifera. Seven new α-pyridones (14-20) were constructed by diversity-oriented synthesis, which has been an effective approach to expanding the chemical space of natural-product-like compounds. Compounds 16, 17, 19, and 20 were found to have inhibitory effect on the gene expression controlled by quorum sensing in Pseudomonas aeruginosa QSIS-lasI.
从源自海洋绿藻浒苔的链霉菌属OUCMDZ-3436的次级代谢产物中鉴定出4个新的α-吡喃酮（1-4）和8个已知类似物（5-12）。通过多样性导向合成构建了7个新的α-吡啶酮（14-20），这是一种扩展类天然产物化合物化学空间的有效方法。发现化合物16、17、19和20对铜绿假单胞菌QSIS-lasI中群体感应控制的基因表达具有抑制作用。
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