Stojković Dejan, Petrović Jovana, Carević Tamara, Soković Marina, Liaras Konstantinos
Department of Plant Physiology, Institute for Biological Research "Siniša Stanković"-National Institute of the Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11000 Belgrade, Serbia.
Department of Life and Health Sciences, School of Sciences and Engineering, University of Nicosia, 2417 Nicosia, Cyprus.
Antibiotics (Basel). 2023 May 25;12(6):963. doi: 10.3390/antibiotics12060963.
This narrative review paper provides an up-to-date overview of the potential of novel synthetic and semisynthetic compounds as antibacterials that target virulence traits in resistant strains. The review focused on research conducted in the last five years and investigated a range of compounds including azoles, indoles, thiophenes, glycopeptides, pleuromutilin derivatives, lactone derivatives, and chalcones. The emergence and spread of antibiotic-resistant bacterial strains is a growing public health concern, and new approaches are urgently needed to combat this threat. One promising approach is to target virulence factors, which are essential for bacterial survival and pathogenesis, but not for bacterial growth. By targeting virulence factors, it may be possible to reduce the severity of bacterial infections without promoting the development of resistance. We discuss the mechanisms of action of the various compounds investigated and their potential as antibacterials. The review highlights the potential of targeting virulence factors as a promising strategy to combat antibiotic resistance and suggests that further research is needed to identify new compounds and optimize their efficacy. The findings of this review suggest that novel synthetic and semisynthetic compounds that target virulence factors have great potential as antibacterials in the fight against antibiotic resistance.
这篇叙述性综述论文提供了关于新型合成和半合成化合物作为针对耐药菌株毒力特征的抗菌剂潜力的最新概述。该综述聚焦于过去五年进行的研究，并研究了一系列化合物，包括唑类、吲哚类、噻吩类、糖肽类、截短侧耳素衍生物、内酯衍生物和查耳酮类。抗生素耐药细菌菌株的出现和传播是一个日益严重的公共卫生问题，迫切需要新的方法来应对这一威胁。一种有前景的方法是针对毒力因子，毒力因子对细菌的生存和发病机制至关重要，但对细菌生长并非必需。通过针对毒力因子，有可能在不促进耐药性发展的情况下降低细菌感染的严重程度。我们讨论了所研究的各种化合物的作用机制及其作为抗菌剂的潜力。该综述强调了针对毒力因子作为对抗抗生素耐药性的一种有前景策略的潜力，并表明需要进一步研究以鉴定新化合物并优化其疗效。这篇综述的结果表明，针对毒力因子的新型合成和半合成化合物在对抗抗生素耐药性方面具有作为抗菌剂的巨大潜力。
