Chen Yan, Zou Ge, Yang Wencong, Zhao Yingying, Tan Qi, Chen Lin, Wang Jinmei, Ma Changyang, Kang Wenyi, She Zhigang
National R & D Center for Edible Fungus Processing Technology, Henan University, Kaifeng 475004, China.
School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China.
Mar Drugs. 2021 Jan 24;19(2):56. doi: 10.3390/md19020056.
One new diterpenoid, diaporpenoid A (), two new sesquiterpenoids, diaporpenoids B-C (,) and three new -pyrone derivatives, diaporpyrones A-C (-) were isolated from an MeOH extract obtained from cultures of the mangrove endophytic fungus sp. QYM12. Their structures were elucidated by extensive analysis of spectroscopic data. The absolute configurations were determined by electronic circular dichroism (ECD) calculations and a comparison of the specific rotation. Compound had an unusual 5/10/5-fused tricyclic ring system. Compounds and showed potent anti-inflammatory activities by inhibiting the production of nitric oxide (NO) in lipopolysaccharide (LPS)-induced RAW264.7 cells with IC values of 21.5 and 12.5 μM, respectively.
从红树内生真菌QYM12菌株培养物的甲醇提取物中分离得到一个新的二萜类化合物——二萜烯类化合物A（）、两个新的倍半萜类化合物——二萜烯类化合物B - C（，）以及三个新的γ-吡喃衍生物——二氢吡喃酮A - C（-）。通过对光谱数据的广泛分析阐明了它们的结构。通过电子圆二色光谱（ECD）计算和比旋光度比较确定了绝对构型。化合物具有不寻常的5/10/5稠合三环体系。化合物和通过抑制脂多糖（LPS）诱导的RAW264.7细胞中一氧化氮（NO）的产生表现出较强的抗炎活性，IC值分别为21.5和12.5 μM。
