Clin Nucl Med. 2018 Apr;43(4):287-288. doi: 10.1097/RLU.0000000000001985.
In this case of suspected sphenoid wing meningioma, Ga-DOTATATE PET/CT showed a somatostatin receptor (SSR)-expressing tumor with extension to the nasopharynx and SSR-expressing cervical lymph nodes. Subsequent biopsy from the nasopharynx revealed an Epstein-Barr virus (EBV)-associated, undifferentiated World Health Organization type 3 nasopharyngeal carcinoma (NPC), a potential clinical pitfall due to the reported high SSR expression of this tumor subtype. In consideration of the high target-to-background contrast, SSR ligands might be superior to F-FDG for EBV-associated NPC PET imaging, particularly at the skull base. Somatostatin receptor ligands might furthermore offer interesting theranostic possibilities for patients with advanced/extensive EBV-associated NPC.
在本例疑似蝶骨翼脑膜瘤中，Ga-DOTATATE PET/CT 显示一种生长抑素受体（SSR）表达肿瘤，延伸至鼻咽部和 SSR 表达的颈部淋巴结。随后鼻咽部活检显示一种与 EBV 相关的、未分化的世界卫生组织 3 型鼻咽癌（NPC），这是一个潜在的临床陷阱，因为据报道这种肿瘤亚型具有高 SSR 表达。考虑到高靶与背景的对比度，SSR 配体可能优于 F-FDG 用于 EBV 相关 NPC 的 PET 成像，特别是在颅底。生长抑素受体配体可能为晚期/广泛 EBV 相关 NPC 患者提供有趣的治疗选择。
