危地马拉和巴西患者鼻咽癌中的爱泼斯坦-巴尔病毒
Epstein-Barr Virus in Nasopharyngeal Carcinoma of Guatemalan and Brazilian Patients.
作者信息
Rumayor Piña Alicia, Dos Santos Harim Tavares, Carlos Roman, Altemani Albina, de Almeida Oslei Paes
机构信息
1 University of Campinas (UNICAMP), Piracicaba, Brazil.
2 Centro Clínico de Cabeza y Cuello/Hospital Herrera Llerandi, Ciudad de Guatemala, Guatemala.
出版信息
Int J Surg Pathol. 2017 Jun;25(4):304-309. doi: 10.1177/1066896916679518. Epub 2016 Nov 23.
BACKGROUND
Nasopharyngeal carcinoma (NPC) is highly associated with Epstein-Barr virus (EBV), particularly the undifferentiated nonkeratinizing subtype. Prevalence of EBV in NPC in countries such as Guatemala and Brazil has not been studied.
METHODS
We analyzed 19 cases of NPC, 11 from Guatemala and 8 from Brazil, for the presence of EBV by in situ hybridization and immunohistochemistry. Additionally, 19 hyperplastic adenoids from children were analyzed for EBV by in situ hybridization, 12 from Guatemala and 7 from Brazil.
RESULTS
All the NPC cases from Guatemala and 5 from Brazil were of the undifferentiated nonkeratinizing type. EBV-negative cases comprised 2 keratinizing NPC and 1 differentiated nonkeratinizing NPC. All undifferentiated nonkeratinizing NPC from both samples showed intense positivity for EBER, while LMP-1 only focally and scarcely expressed. EBER was positive in 75% and 43% of the adenoids from Guatemala and Brazil, respectively.
CONCLUSIONS
All undifferentiated nonkeratinizing NPC irrespective of origin from Guatemala or Brazil were highly associated with EBV.
背景
鼻咽癌（NPC）与爱泼斯坦-巴尔病毒（EBV）高度相关，尤其是未分化非角化亚型。危地马拉和巴西等国鼻咽癌中EBV的流行情况尚未得到研究。
方法
我们通过原位杂交和免疫组化分析了19例鼻咽癌病例，其中11例来自危地马拉，8例来自巴西，以检测EBV的存在。此外，通过原位杂交分析了19例儿童增生性腺样体，其中12例来自危地马拉，7例来自巴西。
结果
危地马拉的所有鼻咽癌病例以及巴西的5例病例均为未分化非角化型。EBV阴性病例包括2例角化性鼻咽癌和1例分化型非角化性鼻咽癌。两个样本中所有未分化非角化型鼻咽癌均显示EBER强阳性，而LMP-1仅局灶性且极少表达。危地马拉和巴西的腺样体中，EBER阳性率分别为75%和43%。
结论
所有未分化非角化型鼻咽癌，无论来自危地马拉还是巴西，均与EBV高度相关。
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