• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

How Does Melittin Permeabilize Membranes?

作者信息

Wimley William C

机构信息

Department of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, Louisiana.

出版信息

Biophys J. 2018 Jan 23;114(2):251-253. doi: 10.1016/j.bpj.2017.11.3738.

DOI:10.1016/j.bpj.2017.11.3738
PMID:29401422
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5984972/
Abstract
摘要

相似文献

1
How Does Melittin Permeabilize Membranes?蜂毒肽是如何使细胞膜通透的？
Biophys J. 2018 Jan 23;114(2):251-253. doi: 10.1016/j.bpj.2017.11.3738.
2
Lipopolysaccharides in bacterial membranes act like cholesterol in eukaryotic plasma membranes in providing protection against melittin-induced bilayer lysis.细菌细胞膜中的脂多糖在抵御蜂毒肽诱导的双层膜裂解方面，其作用类似于真核细胞质膜中的胆固醇。
Biochemistry. 2003 Feb 4;42(4):1101-8. doi: 10.1021/bi026932s.
3
The interaction of bee melittin with lipid bilayer membranes.蜂毒肽与脂质双层膜的相互作用。
Biochim Biophys Acta. 1978 Jun 16;510(1):75-86. doi: 10.1016/0005-2736(78)90131-1.
4
The structure of melittin in membranes.蜂毒肽在膜中的结构。
Biophys J. 1986 Oct;50(4):573-82. doi: 10.1016/S0006-3495(86)83497-X.
5
Melittin-Induced Permeabilization, Re-sealing, and Re-permeabilization of E. coli Membranes.蜂毒素诱导的大肠杆菌膜的通透性、再封闭和再通透化。
Biophys J. 2018 Jan 23;114(2):368-379. doi: 10.1016/j.bpj.2017.10.046.
6
[Cloning and expression of a gene encoding shortened LfcinB(1-15)-Melittin(5-12) hybrid peptide in Escherichia coli BL21(DE3)].[编码缩短的LfcinB(1-15)-蜂毒肽(5-12)杂合肽的基因在大肠杆菌BL21(DE3)中的克隆与表达]
Sheng Wu Gong Cheng Xue Bao. 2009 Jul;25(7):975-81.
7
Melittin and its potential in the destruction and inhibition of the biofilm formation by Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa isolated from bovine milk.蜂毒素及其对金黄色葡萄球菌、大肠杆菌和绿脓假单胞菌在牛乳制品中形成生物膜的破坏和抑制作用。
Microb Pathog. 2017 Nov;112:57-62. doi: 10.1016/j.micpath.2017.09.046. Epub 2017 Sep 21.
8
Dynamics of melittin in water and membranes as determined by fluorescence anisotropy decay.通过荧光各向异性衰减测定的蜂毒肽在水和膜中的动力学。
Biophys J. 1988 Nov;54(5):817-27. doi: 10.1016/S0006-3495(88)83019-4.
9
Postantibiotic effect of purified melittin from honeybee (Apis mellifera) venom against Escherichia coli and Staphylococcus aureus.蜜蜂（意大利蜜蜂）毒液中纯化蜂毒肽对大肠杆菌和金黄色葡萄球菌的抗生素后效应
J Asian Nat Prod Res. 2009 Sep;11(9):796-804. doi: 10.1080/10286020903164277.
10
Cell-selective lysis by novel analogues of melittin against human red blood cells and Escherichia coli.新型蜂毒素类似物对人红细胞和大肠杆菌的细胞选择性裂解作用。
Biochemistry. 2010 Sep 14;49(36):7920-9. doi: 10.1021/bi100729m.

引用本文的文献

1
A Single-Molecule Liposome Assay for Membrane Permeabilization.一种用于膜通透性检测的单分子脂质体分析方法。
Angew Chem Int Ed Engl. 2025 Jun 24;64(26):e202503678. doi: 10.1002/anie.202503678. Epub 2025 Jun 5.
2
Electrochemiluminescence Imaging of Liposome Permeabilization by an Antimicrobial Peptide: Melittin.抗菌肽蜂毒素使脂质体通透化的电化学发光成像
Chem Biomed Imaging. 2023 Mar 6;1(1):58-65. doi: 10.1021/cbmi.3c00003. eCollection 2023 Apr 24.
3
Melittin can permeabilize membranes via large transient pores.蜂毒素可以通过大的瞬时孔使膜穿孔。
Nat Commun. 2024 Aug 23;15(1):7281. doi: 10.1038/s41467-024-51691-1.
4
Hosts and Heterologous Expression Strategies of Recombinant Toxins for Therapeutic Purposes.宿主和异源表达策略的重组毒素用于治疗目的。
Toxins (Basel). 2023 Dec 13;15(12):699. doi: 10.3390/toxins15120699.
5
Effect of CM15 on Supported Lipid Bilayer Probed by Atomic Force Microscopy.原子力显微镜探测CM15对支撑脂质双层的影响。
Membranes (Basel). 2023 Oct 28;13(11):864. doi: 10.3390/membranes13110864.
6
Delivery of Melittin as a Lytic Agent via Graphene Nanoparticles as Carriers to Breast Cancer Cells.通过石墨烯纳米颗粒作为载体将蜂毒素作为一种溶解剂递送至乳腺癌细胞。
J Funct Biomater. 2022 Dec 7;13(4):278. doi: 10.3390/jfb13040278.
7
Rational Design of a Hybrid Peptide against Severe Acute Respiratory Syndrome Coronavirus 2 Using Melittin and Angiotensin-Converting Enzyme 2 as Pharmaceutical Agents.利用蜂毒肽和血管紧张素转换酶2作为药物制剂针对严重急性呼吸综合征冠状病毒2的杂合肽的合理设计
Adv Biomed Res. 2022 Oct 29;11:88. doi: 10.4103/abr.abr_341_21. eCollection 2022.
8
Heterogeneous Structural Disturbance of Cell Membrane by Peptides with Modulated Hydrophobic Properties.具有调控疏水性质的肽对细胞膜的异质性结构干扰
Pharmaceutics. 2022 Nov 15;14(11):2471. doi: 10.3390/pharmaceutics14112471.
9
Organizations of melittin peptides after spontaneous penetration into cell membranes.蜂毒肽自发穿透细胞膜后的构象。
Biophys J. 2022 Nov 15;121(22):4368-4381. doi: 10.1016/j.bpj.2022.10.002. Epub 2022 Oct 4.
10
CL-ACP: a parallel combination of CNN and LSTM anticancer peptide recognition model.CL-ACP：CNN 和 LSTM 抗癌肽识别模型的并联组合。
BMC Bioinformatics. 2021 Oct 20;22(1):512. doi: 10.1186/s12859-021-04433-9.

本文引用的文献

1
Melittin-Induced Permeabilization, Re-sealing, and Re-permeabilization of E. coli Membranes.蜂毒素诱导的大肠杆菌膜的通透性、再封闭和再通透化。
Biophys J. 2018 Jan 23;114(2):368-379. doi: 10.1016/j.bpj.2017.10.046.
2
Translocation of cationic amphipathic peptides across the membranes of pure phospholipid giant vesicles.阳离子两亲性肽跨纯磷脂巨型囊泡膜的转运
J Am Chem Soc. 2013 Nov 6;135(44):16517-25. doi: 10.1021/ja407451c. Epub 2013 Oct 23.
3
The electrical response of bilayers to the bee venom toxin melittin: evidence for transient bilayer permeabilization.双层膜对蜂毒毒素蜂毒素的电反应：瞬时双层膜通透性的证据。
Biochim Biophys Acta. 2013 May;1828(5):1357-64. doi: 10.1016/j.bbamem.2013.01.021. Epub 2013 Feb 4.
4
Determining the mechanism of membrane permeabilizing peptides: identification of potent, equilibrium pore-formers.确定膜通透肽的作用机制：鉴定强效平衡型成孔剂。
Biochim Biophys Acta. 2012 Jul;1818(7):1625-32. doi: 10.1016/j.bbamem.2012.02.009.
5
A combined pulse EPR and Monte Carlo simulation study provides molecular insight on peptide-membrane interactions.一项结合脉冲电子顺磁共振和蒙特卡罗模拟的研究提供了关于肽与膜相互作用的分子见解。
J Phys Chem B. 2009 Sep 24;113(38):12687-95. doi: 10.1021/jp905129b.
6
From "carpet" mechanism to de-novo designed diastereomeric cell-selective antimicrobial peptides.从“地毯”机制到全新设计的非对映体细胞选择性抗菌肽。
Peptides. 2001 Oct;22(10):1629-41. doi: 10.1016/s0196-9781(01)00498-3.
7
Barrel-stave model or toroidal model? A case study on melittin pores.桶板模型还是环形模型？关于蜂毒肽孔的案例研究。
Biophys J. 2001 Sep;81(3):1475-85. doi: 10.1016/S0006-3495(01)75802-X.
8
Structure, location, and lipid perturbations of melittin at the membrane interface.蜂毒肽在膜界面的结构、位置及脂质扰动
Biophys J. 2001 Feb;80(2):801-11. doi: 10.1016/S0006-3495(01)76059-6.
9
Sizing membrane pores in lipid vesicles by leakage of co-encapsulated markers: pore formation by melittin.通过共包封标记物的泄漏来确定脂质囊泡中的膜孔大小：蜂毒肽形成的孔
Biophys J. 1997 Apr;72(4):1762-6. doi: 10.1016/S0006-3495(97)78822-2.
10
The sting. Melittin forms channels in lipid bilayers.蜂毒肽。蜂毒肽在脂质双层中形成通道。
Biophys J. 1981 Oct;36(1):109-16. doi: 10.1016/S0006-3495(81)84719-4.