基于聚电解质/聚苯乙烯磺酸导电层的压阻式微悬臂梁聚合物柔性免疫传感器。
Polymeric Flexible Immunosensor Based on Piezoresistive Micro-Cantilever with PEDOT/PSS Conductive Layer.
机构信息
School of Instrument and Electronics, North University of China, Taiyuan 030051, China.
出版信息
Sensors (Basel). 2018 Feb 3;18(2):451. doi: 10.3390/s18020451.
In this paper, a fully polymeric micro-cantilever with the surface passivation layer of parylene-C and the strain resistor of poly(3,4-ethylenedioxythiophene)/poly (styrene sulfonate) (PEDOT/PSS) was proposed and demonstrated for immunoassays. By optimizing the design and fabrication of the polymeric micro-cantilever, a square resistance of 220 Ω/□ for PEDOT/PSS conductive layer have been obtained. The experimental spring constant and the deflection sensitivity were measured to be 0.017 N/m and 8.59 × 10 nm, respectively. The biological sensing performances of polymeric micro-cantilever were investigated by the immunoassay for human immunoglobulin G (IgG). The immunosensor was experimentally demonstrated to have a linear behavior for the detection of IgG within the concentrations of 10~100 ng/mL with a limit of detection (LOD) of 10 ng/mL. The experimental results indicate that the proposed polymeric flexible conductive layer-based sensors are capable of detecting trace biological substances.
本文提出并展示了一种具有聚对二甲苯表面钝化层和聚(3,4-亚乙基二氧噻吩)/聚(苯乙烯磺酸盐)（PEDOT/PSS）应变电阻器的全聚合物微悬臂梁，用于免疫分析。通过优化聚合物微悬臂梁的设计和制造，获得了 PEDOT/PSS 导电层的方块电阻为 220 Ω/□。实验测量得到的弹性常数和挠度灵敏度分别为 0.017 N/m 和 8.59×10nm。通过免疫测定人免疫球蛋白 G（IgG）研究了聚合物微悬臂梁的生物传感性能。实验结果表明，所提出的基于聚合物柔性导电层的传感器能够在 10100ng/mL 的浓度范围内检测 IgG，检测限（LOD）为 10ng/mL。实验结果表明，所提出的基于聚合物柔性导电层的传感器能够在 10100ng/mL 的浓度范围内检测 IgG，检测限（LOD）为 10ng/mL。实验结果表明，所提出的基于聚合物柔性导电层的传感器能够在 10100ng/mL 的浓度范围内检测 IgG，检测限（LOD）为 10ng/mL。实验结果表明，所提出的基于聚合物柔性导电层的传感器能够在 10100ng/mL 的浓度范围内检测 IgG，检测限（LOD）为 10ng/mL。
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