在没有派尔集合淋巴结的大鼠中诱导口服耐受。
Induction of oral tolerance in rats without Peyer's patches.
作者信息
Enders G, Gottwald T, Brendel W
出版信息
Immunology. 1986 Jun;58(2):311-4.
The induction of oral tolerance after ingestion of antigen has been reported in several animal models. The precise mechanisms responsible for this unresponsiveness are not well understood. As some investigations have suggested a key role of Peyer's patches suppressor T cells, an animal model was developed in which the PP were surgically removed. Using this model, the influence of the PP on the induction of oral tolerance against SRBC was investigated. In order to induce tolerance, the rats were fed SRBC on four consecutive days. On Day 5 they were i.p. challenged by injection of SRBC, and 5 days later the number of immunoglobulin-secreting cells against SRBC was determined within the spleen. Using this protocol, the oral tolerance induction could be shown very clearly in control animals as well as in rats without PP. Therefore, tolerance induction is possible in the absence of PP-T cells. Other mechanisms must be responsible for the tolerance induction in this model.
在多种动物模型中均报道了摄入抗原后诱导口服耐受的情况。导致这种无反应性的确切机制尚不清楚。由于一些研究表明派尔集合淋巴结抑制性T细胞起关键作用，因此建立了一种通过手术切除派尔集合淋巴结的动物模型。利用该模型，研究了派尔集合淋巴结对诱导针对绵羊红细胞（SRBC）的口服耐受的影响。为了诱导耐受，连续四天给大鼠喂食绵羊红细胞。在第5天，通过注射绵羊红细胞对它们进行腹腔内攻击，5天后测定脾脏内针对绵羊红细胞的免疫球蛋白分泌细胞数量。采用该方案，在对照动物以及没有派尔集合淋巴结的大鼠中都能非常清楚地显示口服耐受的诱导。因此，在没有派尔集合淋巴结T细胞的情况下也可能诱导耐受。在该模型中，其他机制必定是诱导耐受的原因。
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