Goonan G W, Fouras A, Dubsky S
Opt Express. 2018 Jan 22;26(2):935-950. doi: 10.1364/OE.26.000935.
X-ray velocimetry (XV) has shown promise for investigations into various dynamic biological systems, including the motion of lungs and the flow of blood. Prior research in the field of XV has highlighted the need for both high spatial resolution to resolve features for tracking, and temporal resolution for accurate velocity measurement. In X-ray imaging systems, enhancement of spatial and temporal resolution requires a small focal spot size and high power output respectively, increasing anode power density requirements. In this paper, we present a multi-source XV regime whereby simultaneously illuminating a sample with multiple sources of small focal spot size, overall illumination can be increased whilst maintaining minimal source blurring without increasing power density requirements. Through a series of simulations, we demonstrate the capability for multi-source systems under various practical constraints, such as focal spot size and power density, to provide increased accuracy compared to single source systems.
X射线测速技术（XV）已展现出在研究各种动态生物系统方面的潜力，包括肺部运动和血液流动。XV领域的先前研究强调了对于跟踪特征解析所需的高空间分辨率以及精确速度测量所需的时间分辨率的需求。在X射线成像系统中，空间分辨率和时间分辨率的提高分别需要小焦斑尺寸和高功率输出，这增加了阳极功率密度要求。在本文中，我们提出了一种多源XV模式，通过用多个小焦斑尺寸的源同时照射样品，可以在不增加功率密度要求的情况下增加整体照明，同时保持最小的源模糊。通过一系列模拟，我们证明了在各种实际约束条件下，如焦斑尺寸和功率密度，多源系统与单源系统相比能够提供更高的精度。
