Med Princ Pract. 2018;27(1):39-43. doi: 10.1159/000486747. Epub 2018 Jan 23.
In this study, the aim was to investigate the effect of hyoscine N-butylbromide (HnBB) pretreatment on pain during propofol injection.
In this prospective, randomized, placebo-controlled and double-blind trial, 60 patients scheduled to undergo routine outpatient surgery under general anesthesia were randomly allocated to 2 groups, the HnBB (n = 30) and sodium chloride (n = 30) groups. Twenty seconds after the injection of 20 mg HnBB or 0.9 % sodium chloride, a 50-mg dose of propofol was injected in 2-3 s. Ten seconds later, the pain intensity was assessed using a 4-point scale: no pain (0), mild (1), moderate (2), and severe (3) pain. The Student t test was used for the analysis of parametric data and the Pearson χ2 test for categorical data.
The occurrence of pain in the HnBB group (43.3%) was significantly lower than the control group (73.3%) (p < 0.018). Of the 30 patients in each group, 10 in the control group and 3 in the HnBB group experienced severe pain (p = 0.001).
Pretreatment with 20 mg HnBB significantly reduced propofol injection pain compared to placebo.
本研究旨在探讨氢溴酸东莨菪碱（HnBB）预处理对丙泊酚注射疼痛的影响。
在这项前瞻性、随机、安慰剂对照和双盲试验中，将 60 名拟在全身麻醉下接受常规门诊手术的患者随机分为 HnBB（n=30）和生理盐水（n=30）组。在注射 20mg HnBB 或 0.9%生理盐水 20 秒后，在 2-3 秒内注射 50mg 丙泊酚。10 秒后，使用 4 分制评估疼痛强度：无痛（0）、轻度（1）、中度（2）和重度（3）疼痛。参数数据采用学生 t 检验分析，分类数据采用 Pearson χ2 检验。
HnBB 组（43.3%）疼痛的发生明显低于对照组（73.3%）（p<0.018）。在每组 30 名患者中，对照组有 10 名，HnBB 组有 3 名患者出现重度疼痛（p=0.001）。
与安慰剂相比，预先给予 20mg HnBB 可显著减轻丙泊酚注射疼痛。
