Department of Anesthesiology and Reanimation, Hacettepe University Faculty of Medicine, Ankara, TR-06100, Turkey.
J Clin Anesth. 2011 Jun;23(4):270-4. doi: 10.1016/j.jclinane.2010.09.008.
To investigate whether methylene blue, given before injection of propofol, was effective in reducing the frequency and severity of pain associated with propofol injection.
Prospective, randomized, double-blinded clinical study.
Operating room of a university hospital.
90 adult, ASA physical status 1 and 2 patients undergoing elective surgery.
Patients were randomly allocated to one of three groups of 30 patients each. Group I received 50 mg of methylene blue, Group II received 40 mg of lidocaine, and Group III, the control group, was given normal saline. All drugs were given as a 2.0 mL bolus 45 seconds before propofol administration.
Injection pain using vocal responses, facial grimacing, arm withdrawal, tears, and questioning of the patient were noted. A 4-point scale was used for documenting pain.
Pain frequency was 90% in the saline group, whereas the frequencies were significantly lower in the lidocaine and methylene blue groups (26.7% and 40%, respectively).
Intravenous pretreatment with methylene blue appears to be effective in reducing the pain during propofol injection.
探讨亚甲蓝在异丙酚注射前给药是否能有效减少与异丙酚注射相关的疼痛的频率和严重程度。
前瞻性、随机、双盲临床研究。
一所大学医院的手术室。
90 名接受择期手术的成年 ASA 身体状况 1 和 2 级患者。
患者随机分为三组，每组 30 名。第 I 组接受 50 毫克亚甲蓝，第 II 组接受 40 毫克利多卡因，第 III 组（对照组）给予生理盐水。所有药物均在异丙酚给药前 45 秒内以 2.0 毫升推注给予。
通过声音反应、面部扭曲、手臂退缩、流泪和询问患者来记录注射疼痛。使用 4 分制记录疼痛。
盐水组疼痛频率为 90%，而利多卡因和亚甲蓝组的疼痛频率明显较低（分别为 26.7%和 40%）。
静脉内预先给予亚甲蓝似乎能有效减轻异丙酚注射时的疼痛。
