二嗪农对心脏和骨骼肌酶活性的治疗效果。

Diazinon treatment effects on heart and skeletal muscle enzyme activities.

作者信息

Wilkinson J G, Rajendra W, Oloffs P C, Banister E W

出版信息

J Environ Sci Health B. 1986 Apr;21(2):103-13. doi: 10.1080/03601238609372513.

Abstract

The effect of low levels of diazinon treatment on four marker enzymes in rat heart and skeletal muscle have been investigated. Adult male Wistar rats were treated twice a week with a dose of 0.5 ml X kg-1 X day-1 diazinon for 28 weeks. Diazinon treated rats gained significantly less weight than Sham-treated controls. Typical differences in Succinate dehydrogenase (SDH), Lactate dehydrogenase (LDH), Phosphofructo kinase (PFK) and Hexokinase (HK) activities were observed between heart and skeletal muscles. Diazinon feeding had no effect on heart, soleus, gastrocnemius and plantaris SDH, LDH and PFK enzyme activities after 28 weeks. HK activity was significantly increased in sham-control soleus and plantaris muscles after 28 weeks. Diazinon feeding inhibited HK activity in plantaris muscle after 28 weeks treatment. These results demonstrate that chronic low levels of diazinon have little effect on the glycolytic and oxidative activity in heart and skeletal muscle.

摘要

研究了低剂量二嗪农处理对大鼠心脏和骨骼肌中四种标志酶的影响。成年雄性Wistar大鼠每周接受两次剂量为0.5 ml·kg⁻¹·d⁻¹的二嗪农处理，持续28周。经二嗪农处理的大鼠体重增加明显少于假处理对照组。在心脏和骨骼肌之间观察到琥珀酸脱氢酶（SDH）、乳酸脱氢酶（LDH）、磷酸果糖激酶（PFK）和己糖激酶（HK）活性的典型差异。喂养二嗪农28周后，对心脏、比目鱼肌、腓肠肌和跖肌的SDH、LDH和PFK酶活性没有影响。28周后，假处理对照组的比目鱼肌和跖肌中HK活性显著增加。处理28周后，喂养二嗪农抑制了跖肌中的HK活性。这些结果表明，长期低剂量的二嗪农对心脏和骨骼肌的糖酵解和氧化活性影响很小。