Raveendranthan Dhanya, Rao Naren P, Rao Mukund G, Mangot Ajish G, Varambally Shivaram, Kesavan Muralidharan, Venkatasubramanian Ganesan, Gangadhar Bangalore N
Department of Psychiatry, St. John's Medical College Hospital, Bengaluru, Karnataka, India.
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
Indian J Psychol Med. 2018 Jan-Feb;40(1):38-40. doi: 10.4103/IJPSYM.IJPSYM_147_17.
Antipsychotic treatment-induced hyperprolactinemia is a highly distressing and disabling side effect for patients. The use of add-on aripiprazole has been identified as a possible treatment strategy in this situation. However, data on prolactin changes with add-on aripiprazole in a real-world naturalistic clinical setting from India are sparse.
The retrospective chart review was conducted at the specialty metabolic clinic at the National Institute of Mental Health and Neurosciences, Bengaluru, India. Sixteen patients (female: male = 13:3) who were on a stable dose of antipsychotic medications, complaining of either sexual dysfunction or menstrual irregularities, were prescribed add-on aripiprazole. The serum prolactin values were obtained before the initiation of aripiprazole and during the follow-up.
Patients were on treatment with risperidone, amisulpride, and olanzapine and had a prolactin level of 87.1 ± 60.7 ng/ml. Add-on aripiprazole treatment was given with a mean dose of 13.8 ± 7.4 mg/day. Patients had a significant reduction in prolactin level (35.6 ± 29.1 ng/ml) following treatment with aripiprazole ( = 0.004).
Add-on aripiprazole could be a clinically useful strategy in patients who develop antipsychotic-induced hyperprolactinemia.
抗精神病药物治疗引起的高催乳素血症对患者来说是一种极其痛苦且致残的副作用。在这种情况下，加用阿立哌唑已被确定为一种可能的治疗策略。然而，来自印度现实世界自然临床环境中关于加用阿立哌唑后催乳素变化的数据却很稀少。
在印度班加罗尔国家心理健康和神经科学研究所的专科代谢诊所进行了回顾性病历审查。16例（女性：男性 = 13:3）正在服用稳定剂量抗精神病药物且抱怨性功能障碍或月经不调的患者，被处方加用阿立哌唑。在开始使用阿立哌唑之前以及随访期间获取血清催乳素值。
患者正在接受利培酮、氨磺必利和奥氮平治疗，催乳素水平为87.1±60.7 ng/ml。加用阿立哌唑治疗的平均剂量为13.8±7.4 mg/天。使用阿立哌唑治疗后患者的催乳素水平显著降低（35.6±29.1 ng/ml）（P = 0.004）。
对于发生抗精神病药物所致高催乳素血症的患者，加用阿立哌唑可能是一种临床上有用的策略。
