Medical School of South China University of Technology, Guangdong 510006, China.
Histology and Embryology Department of Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
Mediators Inflamm. 2017;2017:3513651. doi: 10.1155/2017/3513651. Epub 2017 Dec 18.
() is an important food-borne parasitic disease. Previous study showed that infection can cause demyelination in the central nerve system, but the mechanism of action has not been understood. To explore the mechanism and to look for effective therapeutic methods, interleukin 17A (IL-17A) and iNOS expressions were detected during infection. In addition, IL-17A-neutralizing antibody was applied to treat . infected mice. In our results, we found that IL-17A and iNOS RNA expressions increased gradually in the process of . infection. When infected mice were treated with IL-17A-neutralizing antibody, the pathologic changes of demyelination alleviated obviously, followed with the elevation of myelin basic protein (MBP) in the brain. In addition, the iNOS expression of the brain in infected animals also showed a decrease in astrocytes. Our study provided evidence that IL-17A may take part in the demyelination caused by . and inhibiting IL-17A expression can ameliorate the pathologic changes of demyelination. Moreover, the decreasing of iNOS expression may be the key reason for the effect of IL-17A inhibition on demyelination caused by .
（）是一种重要的食源性寄生虫病。先前的研究表明，（）感染可导致中枢神经系统脱髓鞘，但作用机制尚不清楚。为了探讨其机制并寻找有效的治疗方法，检测了白细胞介素 17A（IL-17A）和诱导型一氧化氮合酶（iNOS）在（）感染过程中的表达。此外，还应用白细胞介素 17A 中和抗体治疗（）感染的小鼠。在我们的研究结果中，我们发现白细胞介素 17A 和 iNOS RNA 的表达在（）感染过程中逐渐增加。当用白细胞介素 17A 中和抗体治疗感染小鼠时，脱髓鞘的病理变化明显缓解，同时大脑中的髓鞘碱性蛋白（MBP）水平升高。此外，感染动物大脑中的 iNOS 表达在星形胶质细胞中也出现下降。我们的研究提供了证据表明，白细胞介素 17A 可能参与了（）感染引起的脱髓鞘，抑制白细胞介素 17A 的表达可以改善脱髓鞘的病理变化。此外，iNOS 表达的降低可能是白细胞介素 17A 抑制（）感染引起的脱髓鞘的关键原因。
