South Australian Institute of Ophthalmology, University of Adelaide, Adelaide, Australia.
Department of Ophthalmology, The Royal Adelaide Hospital, Port Road, Adelaide, SA, 5000, Australia.
Osteoporos Int. 2019 May;30(5):1117-1120. doi: 10.1007/s00198-019-04850-w. Epub 2019 Jan 23.
To report two cases of bisphosphonate-induced orbital inflammation, discuss the clinic-radiological features and management options, and highlight the increasing frequency of an association previously considered extremely rare. A retrospective review of two cases presenting to our department, and review of the literature reporting this association. Two new cases of bisphosphonate-induced orbital inflammation were added to the literature. The first occurred in the context of a risedronate re-challenge, and the second with zoledronic acid. Both cases were managed successfully with topical steroids. Clinicians prescribing bisphosphonates, particularly for the first time, should be aware of the increasingly reported association with orbital inflammation. The presence of suggestive clinical features should prompt urgent referral to an ophthalmologist for appropriate management.
报告两例双膦酸盐诱导的眼眶炎症病例，讨论其临床-影像学特征和治疗选择，并强调以前被认为极为罕见的关联的发生频率不断增加。对我们科室就诊的两例病例进行回顾性分析，并对文献中报告的该关联进行综述。两例新的双膦酸盐诱导的眼眶炎症病例被添加到文献中。第一例发生在利塞膦酸钠再挑战的情况下，第二例发生在唑来膦酸的情况下。两种情况均成功地通过局部皮质类固醇治疗。首次开具双膦酸盐处方的临床医生，特别是应该意识到与眼眶炎症的日益报道的关联。存在提示性临床特征时，应立即转介给眼科医生进行适当治疗。
