淋巴细胞刀豆球蛋白A帽化：唐氏综合征与早发性原发性退行性痴呆之间的相似性。
Lymphocyte concanavalin A capping: a similarity between Down's syndrome and early onset primary degenerative dementia.
作者信息
Duijndam-van den Berge M, Goekoop J G
出版信息
J Neurol Neurosurg Psychiatry. 1986 May;49(5):595-8. doi: 10.1136/jnnp.49.5.595.
Abstract
Lymphocyte capping with concanavalin A was studied in adult patients with Down's syndrome and aged patients with primary degenerative dementia. In both disorders a decreased capping was found as compared with age-matched and clinically relevant control groups. Colchicine had a strong enhancing effect on capping in Down's syndrome. In primary degenerative dementia the enhancing effect of colchicine was restricted to a subgroup of patients with onset of the dementing illness before the age of 80 years.
摘要
在成年唐氏综合征患者和老年原发性退行性痴呆患者中研究了伴刀豆球蛋白A诱导的淋巴细胞帽形成。与年龄匹配且临床相关的对照组相比，在这两种疾病中均发现帽形成减少。秋水仙碱对唐氏综合征患者的帽形成有强烈的增强作用。在原发性退行性痴呆中，秋水仙碱的增强作用仅限于80岁之前发病的痴呆患者亚组。
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