Haan J, Demmers R T, Buruma O J, Roos R A
Department of Neurology, University Hospital, Leiden, The Netherlands.
J Neurol. 1990 Apr;237(2):117-9. doi: 10.1007/BF00314675.
Lymphocyte capping with concanavalin A was studied in 11 patients with hereditary cerebral haemorrhage with amyloidosis (Dutch type) and 10 controls. No difference in capping was found between patients and controls. Abnormal lymphocyte concanavalin A capping has been reported in patients with the Icelandic type of cerebral amyloidosis and in patients with Alzheimer's disease, a disease in which cerebral amyloid angiopathy can also be found. The results suggest a difference in pathogenesis between the Dutch type of cerebral amyloidosis and the other amyloid diseases.
对11例遗传性脑出血伴淀粉样变性（荷兰型）患者和10名对照者进行了伴刀豆球蛋白A介导的淋巴细胞帽化研究。患者和对照者之间在帽化方面未发现差异。据报道，冰岛型脑淀粉样变性患者和阿尔茨海默病患者（一种也可发现脑淀粉样血管病的疾病）存在异常的淋巴细胞伴刀豆球蛋白A帽化现象。结果表明，荷兰型脑淀粉样变性与其他淀粉样疾病在发病机制上存在差异。
