Krajewski S, Szablowska-Krajewska M
J Neurol Sci. 1986 Feb;72(2-3):131-45. doi: 10.1016/0022-510x(86)90002-x.
Histological examination of 20 sciatic nerves from rabbits with experimental chronic serum sickness (CHSS) revealed patchy vasculitis of the vasa nervorum of various intensity. The vessel lesions ranged from endothelial proliferation to vessel wall necrosis with fibrinoid degeneration and infiltration by lymphocytes, plasma cells, macrophages and, sporadically, by neutrophils. Perivascularly, there were oedema, chronic infiltrates or small haemorrhages. The myelinated fibres in close relation to the vascular system were focally depleted and features of perivascular demyelination were found. Teased fibres showed paranodal and segmental demyelination, axonal degeneration and, sporadically, remyelination. In all cases, immunofluorescent deposits of bovine serum albumin (BSA), IgG and C3 complement were found in and around some vasa nervorum. Other indirect evidence for immune complex (IC) deposition was provided by ultrastructural examination where vascular and endoneurial osmophilic deposits were found; in 4 cases with paracrystalline organization resembling cryoglobulin component. IC-mediated vasculitis led to blood-nerve barrier impairment and leakage of serum proteins into the endoneurial space. The morphological and immunohistochemical changes in this model which develop after a latency period of 2 or more weeks, strongly resemble those observed in human acquired inflammatory demyelinating polyradiculoneuropathies or in connective tissue diseases.
对20只患有实验性慢性血清病（CHSS）的家兔的坐骨神经进行组织学检查，发现神经滋养血管存在不同程度的斑片状血管炎。血管病变范围从内皮细胞增生到血管壁坏死，伴有纤维蛋白样变性，并伴有淋巴细胞、浆细胞、巨噬细胞浸润，偶尔还有中性粒细胞浸润。血管周围有水肿、慢性浸润或小出血。与血管系统密切相关的有髓纤维局部减少，并发现血管周围脱髓鞘的特征。 teased纤维显示结旁和节段性脱髓鞘、轴突变性，偶尔还有再髓鞘化。在所有病例中，在一些神经滋养血管内及其周围发现了牛血清白蛋白（BSA）、IgG和C3补体的免疫荧光沉积物。超微结构检查提供了免疫复合物（IC）沉积的其他间接证据，发现了血管和神经内膜嗜锇沉积物；在4例中，有类似冷球蛋白成分的副晶状组织。IC介导的血管炎导致血神经屏障受损，血清蛋白渗漏到神经内膜间隙。在2周或更长时间的潜伏期后，该模型中出现的形态学和免疫组化变化与人类获得性炎性脱髓鞘性多发性神经根神经病或结缔组织疾病中观察到的变化非常相似。
